Academic Journal
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
| العنوان: | Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission |
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| المؤلفون: | Rivett L., Sridhar S., Sparkes D., Routledge M., Jones N. K., Forrest S., Young J., Pereira-Dias J., Hamilton W. L., Ferris M., Torok M. E., Meredith L., Curran M. D., Fuller S., Chaudhry A., Shaw A., Samworth R. J., Bradley J. R., Dougan G., Smith K. G. C., Lehner P. J., Matheson N. J., Wright G., Goodfellow I. G., Baker S., Weekes M. P., Lyons P. A., Toshner M., Warne B., Scott J. B., Cormie C., Gill H., Kean I., Maes M., Reynolds N., Wantoch M., Caddy S., Caller L., Feltwell T., Hall G., Hosmillo M., Houldcroft C., Jahun A., Khokhar F., Yakovleva A., Butcher H., Caputo D., Clapham-Riley D., Dolling H., Furlong A., Graves B., Gresley E. L., Kingston N., Papadia S., Stark H., Stirrups K. E., Webster J., Calder J., Harris J., Hewitt S., Kennet J., Meadows A., Rastall R., Brien C. O., Price J., Publico C., Rowlands J., Ruffolo V., Tordesillas H., Brookes K., Canna L., Cruz I., Dempsey K., Elmer A., Escoffery N., Jones H., Ribeiro C., Saunders C., Wright A., Nyagumbo R., Roberts A., Bucke A., Hargreaves S., Johnson D., Narcorda A., Read D., Sparke C., Warboys L., Lagadu K., Mactavous L., Gould T., Raine T., Mather C., Ramenatte N., Vallier A. -L., Kasanicki M., Eames P. -J., McNicholas C., Thake L., Bartholomew N., Brown N., Parmar S., Zhang H., Bowring A., Martell G., Quinnell N., Wright J., Murphy H., Dunmore B. J., Legchenko E., Graf S., Huang C., Hodgson J., Hunter K., Martin J., Mescia F., O'donnell C., Pointon L., Shih J., Sutcliffe R., Tilly T., Tong Z., Treacy C., Wood J., Bergamaschi L., Betancourt A., Bowyer G., Sa A. D., Epping M., Hinch A., Huhn O., Jarvis I., Lewis D., Marsden J., McCallum S., Nice F. |
| المساهمون: | Rivett L., Sridhar S., Sparkes D., Routledge M., Jones N. K., Forrest S., Young J., Pereira-Dias J., Hamilton W. L., Ferris M., Torok M. E., Meredith L., Curran M. D., Fuller S., Chaudhry A., Shaw A., Samworth R. J., Bradley J. R., Dougan G., Smith K. G. C., Lehner P. J., Matheson N. J., Wright G., Goodfellow I. G., Baker S., Weekes M. P., Lyons P. A., Toshner M., Warne B., Scott J. B., Cormie C., Gill H., Kean I., Maes M., Reynolds N., Wantoch M., Caddy S., Caller L., Feltwell T., Hall G., Hosmillo M., Houldcroft C., Jahun A., Khokhar F., Yakovleva A., Butcher H., Caputo D., Clapham-Riley D., Dolling H., Furlong A., Graves B., Gresley E. L., Kingston N., Papadia S., Stark H., Stirrups K. E., Webster J., Calder J., Harris J., Hewitt S., Kennet J., Meadows A., Rastall R., Brien C. O., Price J., Publico C., Rowlands J., Ruffolo V., Tordesillas H., Brookes K., Canna L., Cruz I., Dempsey K., Elmer A., Escoffery N., Jones H., Ribeiro C., Saunders C., Wright A., Nyagumbo R., Roberts A., Bucke A., Hargreaves S., Johnson D., Narcorda A., Read D., Sparke C., Warboys L., Lagadu K., Mactavous L., Gould T., Raine T., Mather C., Ramenatte N., Vallier A. -L., Kasanicki M., Eames P. -J., Mcnicholas C., Thake L., Bartholomew N. |
| سنة النشر: | 2020 |
| المجموعة: | Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| مصطلحات موضوعية: | COVID-19, SARS-CoV-2, emerging pathogen, epidemiology, global health, human, human biology, infectious disease, medicine, occupational health, virology, viru, Betacoronaviru, COVID-19 Testing, COVID-19 Vaccine, Coronavirus Infection, Female, Infection Control, Male, Pandemic, Pneumonia, Viral, Real-Time Polymerase Chain Reaction, United Kingdom, Asymptomatic Infection, Clinical Laboratory Technique, Health Personnel |
| الوصف: | Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3-week period (April 2020), 1,032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19) >7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B·1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32392129; info:eu-repo/semantics/altIdentifier/wos/WOS:000543747200001; volume:9; journal:ELIFE; http://hdl.handle.net/11379/562821; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85085941159 |
| DOI: | 10.7554/eLife.58728 |
| الاتاحة: | http://hdl.handle.net/11379/562821 https://doi.org/10.7554/eLife.58728 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5E66AF15 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/eLife.58728 |
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