Academic Journal
Comparative Prognostic Value of Parameters of Pulsatile Right Ventricular Afterload in Patients With Advanced Heart Failure Awaiting Heart Transplantation
| العنوان: | Comparative Prognostic Value of Parameters of Pulsatile Right Ventricular Afterload in Patients With Advanced Heart Failure Awaiting Heart Transplantation |
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| المؤلفون: | Rubino, Francesca, Scarsini, Roberto, Piccoli, Anna, San Biagio, Livio, Tropea, Ilaria, Pighi, Michele, Prati, Daniele, Tavella, Domenico, Pesarini, Gabriele, Benfari, Giovanni, Onorati, Francesco, Gottin, Leonardo, Faggian, Giuseppe, Ribichini, Flavio Luciano |
| المساهمون: | Rubino, Francesca, Scarsini, Roberto, Piccoli, Anna, San Biagio, Livio, Tropea, Ilaria, Pighi, Michele, Prati, Daniele, Tavella, Domenico, Pesarini, Gabriele, Benfari, Giovanni, Onorati, Francesco, Gottin, Leonardo, Faggian, Giuseppe, Ribichini, Flavio Luciano |
| سنة النشر: | 2022 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | right ventricle, after load, heart transplantation, heart failure, right ventricular after load |
| الوصف: | Right ventricular pulsatile afterload (RVPA) demonstrated a strong impact on survival of patients with advanced heart failure (HF) with reduced ejection fraction. The best prognostic parameter of RVPA is unknown. The aim of this work was to examine the prognostic relevance of pulmonary artery compliance (PAC), pulmonary artery elastance (PAE), and pulmonary artery pulsatile index (PAPi) in a consecutive cohort of patients with advanced HF evaluated for heart transplantation (HT). A total of 149 patients with end-stage HF underwent right-sided cardiac catheterization and were clinically followed up until death or any censoring events, including HT, left ventricular assist device, and hospitalization for acute HF. The primary endpoint occurred in 29 patients (19.5%) during a median follow-up time of 12 (interquartile range 3 to 34) months. This cohort presented a worse hemodynamic profile than event-free survivors. PAC <1.9 mL/mm Hg (hazard ratio 3, 95% confidence interval 1.3 to 6.0, p=0.007) and PAE >0.9 mmHg/mL (hazard ratio 2.5, 95% confidence interval 1.1 to 5.2, p=0.02) were associated with the adverse outcome. On the contrary, PAPi was not associated with the outcome. PAC demonstrated a superior predictive value for the composite adverse outcome compared with pulmonary vascular resistance (area under the curve comparison p=0.019) and PAPi (p=0.03) but similar compared with PAE (p=0.19) and mean pulmonary arterial pressure (p=0.51). PAC, but not PAE, showed incremental prognostic value compared with cardiac index (p=0.02). In conclusion, hemodynamic indexes of RVPA are associated with worse survival in patients with end-stage HF. PAC and PAE demonstrated superior prognostic value compared with PAPi and pulmonary vascular resistance. Moreover, PAC showed incremental prognostic value compared with cardiac index in patients awaiting HT. ; Right ventricular pulsatile afterload (RVPA) demonstrated a strong impact on survival of patients with advanced heart failure (HF) with reduced ejection fraction. The ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36109208; info:eu-repo/semantics/altIdentifier/wos/WOS:000928393300008; volume:183; firstpage:55; lastpage:61; numberofpages:7; journal:THE AMERICAN JOURNAL OF CARDIOLOGY; http://hdl.handle.net/11562/1074968; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85139241961 |
| DOI: | 10.1016/j.amjcard.2022.08.010 |
| الاتاحة: | http://hdl.handle.net/11562/1074968 https://doi.org/10.1016/j.amjcard.2022.08.010 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5E250DFC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.amjcard.2022.08.010 |
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