Academic Journal
OTTERS:a powerful TWAS framework leveraging summary-level reference data
| العنوان: | OTTERS:a powerful TWAS framework leveraging summary-level reference data |
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| المؤلفون: | Dai, Qile, Zhou, Geyu, Zhao, Hongyu, Võsa, Urmo, Franke, Lude, Battle, Alexis, Teumer, Alexander, Lehtimäki, Terho, Raitakari, Olli T., Esko, Tõnu, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Favé, Marie Julie, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Scholz, Markus, van Meurs, Joyce, Verlouw, Joost, Yang, Jian, Yang, Jingjing |
| المصدر: | Dai , Q , Zhou , G , eQTLgen Consortium , Zhao , H , Võsa , U , Franke , L , Battle , A , Teumer , A , Lehtimäki , T , Raitakari , O T , Esko , T , Agbessi , M , Ahsan , H , Alves , I , Andiappan , A K , Arindrarto , W , Awadalla , P , Battle , A , Beutner , F , Jan Bonder , M , Boomsma , D I , Christiansen , M W , Claringbould , A , Deelen , P .... |
| سنة النشر: | 2023 |
| الوصف: | Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size. Thus, we develop a TWAS framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) that adapts multiple polygenic risk score (PRS) methods to estimate eQTL weights from summary-level eQTL reference data and conducts an omnibus TWAS. We show that OTTERS is a practical and powerful TWAS tool by both simulations and application studies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1038/s41467-023-36862-w |
| الاتاحة: | https://pure.eur.nl/en/publications/a3117c28-9a8c-4508-87d8-1341387b346c https://doi.org/10.1038/s41467-023-36862-w https://pure.eur.nl/ws/files/86640092/OTTERS.pdf http://www.scopus.com/inward/record.url?scp=85149555455&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5E21235F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-36862-w |
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