Academic Journal
Predictors of Occurrence and 30-Day Mortality for Co-Infection of Carbapenem-Resistant Klebsiella pneumoniae and Carbapenem-Resistant Acinetobacter baumannii
| العنوان: | Predictors of Occurrence and 30-Day Mortality for Co-Infection of Carbapenem-Resistant Klebsiella pneumoniae and Carbapenem-Resistant Acinetobacter baumannii |
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| المؤلفون: | Lv, Dongmei, Zuo, Yan, Wang, Yuerong, Wang, Zhongxin, Xu, Yuanhong |
| المساهمون: | Natural Science Foundation of Anhui Province, Anhui Provincial Department of Education |
| المصدر: | Frontiers in Cellular and Infection Microbiology ; volume 12 ; ISSN 2235-2988 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Background The phenomenon of co-infection with multiple carbapenem-resistant bacteria is growing, which pose a great challenge for infection control and treatment. This study aimed to analyze predictors of occurrence and 30-day mortality for carbapenem-resistant Klebsiella pneumoniae and carbapenem-resistant Acinetobacter baumannii co-infection. Methods From June 2018 to June 2021, clinical data of 103 patients co-infected with carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Klebsiella pneumoniae (CRKP) were collected from a tertiary teaching hospital in Anhui Province, China. The clinical characteristics and predictors of mortality were analyzed. Meanwhile, the bacterial isolates were characterized for drug susceptibility, multi-locus sequence typing, and drug resistance genes. Results The multivariate analysis revealed that fiberoptic bronchoscopy ( p = 0.005, OR=2.72), repeat transfusions ( p = 0.008, OR= 2.23) and exposure to tigecycline ( p = 0.002, OR = 6.58) were independent risk factors for CRKP and CRAB co-infection. Neutrophil ≥11.9*10 9 ( p = 0.035, adjusted HR = 3.12) and C-reactive protein ≥ 149 mg/L ( p = 0.009, adjusted HR = 4.41) were found associated with 30-day mortality. Combined neutrophil with C-reactive protein could predict 30-day mortality, of which AUC value was 0.791 (95%CI: 0.661-0.921). KPC (46/51, 90.2%) was the most common carbapenemase in CRKP. 33 isolates of CRKP belong to ST11 (33/51, 64.7%), and three new ST types ST5882, ST5883, ST5885 were detected. Conclusions Invasive operations and antibiotics exposure can lead to CRKP and CRAB co-infection. Combined neutrophil with C-reactive protein could predict 30-day mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fcimb.2022.919414 |
| DOI: | 10.3389/fcimb.2022.919414/full |
| الاتاحة: | http://dx.doi.org/10.3389/fcimb.2022.919414 https://www.frontiersin.org/articles/10.3389/fcimb.2022.919414/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.5DEBD7FB |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fcimb.2022.919414 |
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