Academic Journal
Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
| العنوان: | Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning |
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| المؤلفون: | Román Ivorra, Jose A, Trallero-Araguás, Ernesto, Lopez Lasanta, Maria America, Cebrián, Laura, Lojo, Leticia, López-Muñíz, Belén |
| المساهمون: | Institut Català de la Salut, Román Ivorra JA Reumathology Department, Hospital Politécnico y Universitario La Fe, Valencia, Spain. Trallero-Araguas E, Lopez Lasanta M Servei de Reumatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Cebrián L, Lojo L Rheumatology Department, Hospital Infanta Leonor, Madrid, Spain. López-Muñíz B Pneumology Department, Hospital Infanta Leonor, Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | BMJ |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Aprenentatge automàtic, Artritis reumatoide - Epidemiologia, Pulmons - Malalties - Epidemiologia, DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial, DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid, PHENOMENA AND PROCESSES::Mathematical Concepts::Algorithms::Artificial Intelligence::Machine Learning, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence, ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales, ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis::artritis reumatoide, FENÓMENOS Y PROCESOS::conceptos matemáticos::algoritmos::inteligencia artificial::aprendizaje automático, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::morbilidad::prevalencia |
| الوصف: | Artritis reumatoide; Epidemiologia; Fibrosi pulmonar ; Rheumatoid arthritis; Epidemiology; Pulmonary fibrosis ; Artritis reumatoide; Epidemiología; Fibrosis pulmonar ; Objectives Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR). Methods Observational case–control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019. NLP was used to extract unstructured clinical information from EHR and standardise it into a SNOMED-CT terminology. Prevalence of RA and RAILD were calculated, and a descriptive analysis was performed. Characteristics between patients with RAILD and RA patients without ILD (RAnonILD) were compared. Results From a source population of 3 176 165 patients and 64 241 683 EHRs, 13 958 patients with RA were identified. Of those, 5.1% patients additionally had ILD (RAILD). The overall age-adjusted prevalence of RA and RAILD were 0.53% and 0.02%, respectively. The most common ILD subtype was usual interstitial pneumonia (29.3%). When comparing RAILD versus RAnonILD patients, RAILD patients were older and had more comorbidities, notably concerning infections (33.6% vs 16.5%, p<0.001), malignancies (15.9% vs 8.5%, p<0.001) and cardiovascular disease (25.8% vs 13.9%, p<0.001) than RAnonILD. RAILD patients also had higher inflammatory burden reflected in more pharmacological prescriptions and higher inflammatory parameters and presented a higher in-hospital mortality with a higher risk of death (HR 2.32; 95% CI 1.59 to 2.81, p<0.001). Conclusions We found an estimated age-adjusted prevalence of RA and RAILD by analysing real-world data through NLP. RAILD ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2056-5933 |
| Relation: | RMD Open;10(1); https://doi.org/10.1136/rmdopen-2023-003353; Román Ivorra JA, Trallero-Araguas E, Lopez Lasanta M, Cebrián L, Lojo L, López-Muñíz B, et al. Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning. RMD Open. 2024 Jan;10(1):e003353.; https://hdl.handle.net/11351/11115; 001154950300004 |
| DOI: | 10.1136/rmdopen-2023-003353 |
| الاتاحة: | https://hdl.handle.net/11351/11115 https://doi.org/10.1136/rmdopen-2023-003353 |
| Rights: | Attribution-NonCommercial 4.0 International ; http://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5DDF1FC5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20565933 |
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| DOI: | 10.1136/rmdopen-2023-003353 |