Academic Journal
Liver stiffness and associated risk factors among people with a history of injecting drugs: a prospective cohort study
| العنوان: | Liver stiffness and associated risk factors among people with a history of injecting drugs: a prospective cohort study |
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| المؤلفون: | Druckrey-Fiskaaen, Karl Trygve, Vold, Jørn Henrik, Madebo, Tesfaye, Midgard, Håvard, Dalgard, Olav, Leiva, Rafael Alexander Mo, Fadnes, Lars T. |
| المصدر: | 21 ; Substance Abuse Treatment, Prevention, and Policy ; 19 |
| بيانات النشر: | BMC |
| سنة النشر: | 2024 |
| المجموعة: | University of Bergen: Bergen Open Research Archive (BORA-UiB) |
| الوصف: | Background: Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population. Chronic liver diseases are a substantial cause of this. Screening strategies based on liver stiffness measurements (LSM) may facilitate early detection, timely intervention, and treatment of liver disease. This study aims to investigate the extent of chronic liver disease measured with transient elastography and the association between LSM and various risk factors, including substance use patterns, hepatitis C virus (HCV) infection, alcohol use, body mass index, age, type 2 diabetes mellitus, and high-density lipoprotein (HDL) cholesterol among people with OUD or with SUD who inject substances. Methods: Data was collected from May 2017 to March 2022 in a cohort of 676 persons from Western Norway. The cohort was recruited from two populations: Persons receiving opioid agonist therapy (OAT) (81% of the sample) or persons with SUD injecting substances but not receiving OAT. All participants were assessed at least once with transient elastography. A linear mixed model was performed to assess the impact of risk factors such as HCV infection, alcohol use, lifestyle-associated factors, and substance use on liver stiffness at baseline and over time. Baseline was defined as the time of the first liver stiffness measurement. The results are presented as coefficients (in kilopascal (kPa)) with 95% confidence intervals (CI). Results: At baseline, 12% (n = 83) of the study sample had LSM suggestive of advanced chronic liver disease (LSM ≥ 10 kPa). Advanced age (1.0 kPa per 10 years increments, 95% CI: 0.68;1.3), at least weekly alcohol use (1.3, 0.47;2.1), HCV infection (1.2, 0.55;1.9), low HDL cholesterol level (1.4, 0.64;2.2), and higher body mass index (0.25 per increasing unit, 0.17;0.32) were all significantly associated with higher LSM at baseline. Compared with persistent chronic HCV infection, a resolved HCV ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://hdl.handle.net/11250/3171639; cristin:2264306; Substance Abuse Treatment, Prevention, and Policy. 2024, 19, 21. |
| DOI: | 10.1186/s13011-024-00603-z |
| الاتاحة: | https://hdl.handle.net/11250/3171639 https://doi.org/10.1186/s13011-024-00603-z |
| Rights: | Navngivelse 4.0 Internasjonal ; http://creativecommons.org/licenses/by/4.0/deed.no ; Copyright 2024 the authors |
| رقم الانضمام: | edsbas.5DACC8D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13011-024-00603-z |
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