Academic Journal
Association between diabetes and causes of dementia: Evidence from a clinicopathological study
| العنوان: | Association between diabetes and causes of dementia: Evidence from a clinicopathological study |
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| المؤلفون: | Maria Niures Pimentel dos Santos Matioli, Claudia Kimie Suemoto, Roberta Diehl Rodriguez, Daniela Souza Farias, Magnólia Moreira da Silva, Renata Elaine Paraizo Leite, Renata Eloah Lucena Ferretti-Rebustini, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Lea Tenenholz Grinberg, Ricardo Nitrini |
| المصدر: | Dementia & Neuropsychologia, Vol 11, Iss 4, Pp 406-412 |
| بيانات النشر: | Associação Neurologia Cognitiva e do Comportamento |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | doença de Alzheimer, diabetes mellitus, demência vascular, neuropatologia, estudo clinicopatológico, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Background: Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer's disease (AD) and other causes of dementia. Objective: To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study. Methods: Data were collected from the participants of the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015. Diagnosis of diabetes was reported by the deceased's next-of-kin. Clinical dementia was established when CDR ≥ 1 and IQCODE > 3.41. Dementia etiology was determined by neuropathological examination using immunohistochemistry. The association of diabetes with odds of dementia was investigated using multivariate logistic regression. Results: We included 1,037 subjects and diabetes was present in 279 participants (27%). The prevalence of dementia diagnosis was similar in diabetics (29%) and non-diabetics (27%). We found no association between diabetes and dementia (OR = 1.22; 95%CI = 0.81-1.82; p = 0.34) on the multivariate analysis. AD was the main cause of dementia in both groups, while VaD was the second-most-frequent cause in diabetics. Other mixed dementia was the second-most-common cause of dementia and more frequent among non-diabetics (p = 0.03). Conclusion: Diabetes was not associated with dementia in this large clinicopathological study. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1980-5764 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642017000400406&lng=en&tlng=en; https://doaj.org/toc/1980-5764; https://doaj.org/article/763b9c29e9c44037858ee22a0611c60a |
| DOI: | 10.1590/1980-57642016dn11-040010 |
| الاتاحة: | https://doi.org/10.1590/1980-57642016dn11-040010 https://doaj.org/article/763b9c29e9c44037858ee22a0611c60a |
| رقم الانضمام: | edsbas.5D9A03D6 |
| قاعدة البيانات: | BASE |
| تدمد: | 19805764 |
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| DOI: | 10.1590/1980-57642016dn11-040010 |