Academic Journal
Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation
| العنوان: | Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation |
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| المؤلفون: | Headley, Colwyn A., Gerberick, Abigail, Mehta, Sumiran, Wu, Qian, Yu, Lianbo, Fadda, Paolo, Khan, Mahmood, Ganesan, Latha Prabha, Turner, Joanne, Rajaram, Murugesan V. S. |
| المساهمون: | National Institute on Aging, American Heart Association |
| المصدر: | Aging Cell ; volume 18, issue 3 ; ISSN 1474-9718 1474-9726 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Biological aging dynamically alters normal immune and cardiac function, favoring the production of pro‐inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α) and increased instances of cardiac distress. Cardiac failure is the primary reason for hospitalization of the elderly (65+ years). The elderly are also increasingly susceptible to developing chronic bacterial infections due to aging associated immune abnormalities. Since bacterial infections compound the rates of cardiac failure in the elderly, and this phenomenon is not entirely understood, the interplay between the immune system and cardiovascular function in the elderly is of great interest. Using Mycobacterium avium, an opportunistic pathogen, we investigated the effect of mycobacteria on cardiac function in aged mice. Young (2–3 months) and old (18–20 months) C57BL/6 mice were intranasally infected with M. avium strain 104, and we compared the bacterial burden, immune status, cardiac electrical activity, pathology, and function of infected mice against uninfected age‐matched controls. Herein, we show that biological aging may predispose old mice infected with M. avium to mycobacterial dissemination into the heart tissue and this leads to cardiac dysfunction. M. avium infected old mice had significant dysrhythmia, cardiac hypertrophy, increased recruitment of CD45 + leukocytes, cardiac fibrosis, and increased expression of inflammatory genes in isolated heart tissue. This is the first study to report the effect of mycobacteria on cardiac function in an aged model. Our findings are critical to understanding how nontuberculous mycobacterium (NTM) and other mycobacterial infections contribute to cardiac dysfunction in the elderly population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/acel.12926 |
| الاتاحة: | http://dx.doi.org/10.1111/acel.12926 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Facel.12926 https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12926 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/acel.12926 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.5D7B540 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/acel.12926 |
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