Academic Journal
The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhoea
| العنوان: | The efficacy of bismuth subsalicylate in the treatment of acute diarrhoea and the prevention of persistent diarrhoea |
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| المؤلفون: | Chowdhury, HR, Yunus, M, Zaman, K, Rahman, A, Faruque, SM, Lescano, AG, Sack, RB |
| المصدر: | Acta Paediatrica ; volume 90, issue 6, page 605-610 ; ISSN 0803-5253 1651-2227 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2001 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | A controlled, randomized, double‐blind study in Bangladeshi children (ages 4–36 mo) with acute diarrhoea was undertaken to determine whether bismuth subsalicylate (BSS) would prevent the development of persistent diarrhoea (PD) in young children. The children were randomized to two groups: 226 were given liquid oral BSS, (as Pepto‐Bismol), 100mg/kg/d for 5 d; 225 were given placebo of identical appearance. On admission to the study, the two groups were comparable both clinically and microbiologically. Rotavirus was found in 56% of all the children, and enterotoxigenic E. coli in 31% of a subsample studied. Children treated with BSS had less severe and less prolonged illness than those treated with placebo ( p = 0.057). There was, however, no difference in the development of PD between the two groups (8% and 11%). Unexpectedly, patients treated with BSS gained significantly more weight (2.3%) than those treated with placebo (0.5%; p < 0.001) during the course of the study. No toxicity of BSS was detected. Conclusion : Treatment with BSS had a modest therapeutic effect on acute diarrhoea, as has been previously demonstrated, but with no suggestion of a therapeutic effect on the prevention of persistent diarrhoea in this group of patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1651-2227.2001.tb02420.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1651-2227.2001.tb02420.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1651-2227.2001.tb02420.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1651-2227.2001.tb02420.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.5D74A55A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1651-2227.2001.tb02420.x |
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