Academic Journal
Is Silver Addition to Scaffolds Based on Polycaprolactone Blended with Calcium Phosphates Able to Inhibit Candida albicans and Candida auris Adhesion and Biofilm Formation?
| العنوان: | Is Silver Addition to Scaffolds Based on Polycaprolactone Blended with Calcium Phosphates Able to Inhibit Candida albicans and Candida auris Adhesion and Biofilm Formation? |
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| المؤلفون: | Francesca Menotti, Sara Scutera, Eleonora Maniscalco, Bartolomeo Coppola, Alessandro Bondi, Cristina Costa, Fabio Longo, Narcisa Mandras, Claudia Pagano, Lorenza Cavallo, Giuliana Banche, Mery Malandrino, Paola Palmero, Valeria Allizond |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 5, p 2784 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | poly(ε-caprolactone)-based biomaterial, calcium phosphates, silver, Candida albicans, Candida auris, anti-adhesive/antifungal properties, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Candida spp. periprosthetic joint infections are rare but difficult-to-treat events, with a slow onset, unspecific symptoms or signs, and a significant relapse risk. Treatment with antifungals meets with little success, whereas prosthesis removal improves the outcome. In fact, Candida spp. adhere to orthopedic devices and grow forming biofilms that contribute to the persistence of this infection and relapse, and there is insufficient evidence that the use of antifungals has additional benefits for anti-biofilm activity. To date, studies on the direct antifungal activity of silver against Candida spp. are still scanty. Additionally, polycaprolactone (PCL), either pure or blended with calcium phosphate, could be a good candidate for the design of 3D scaffolds as engineered bone graft substitutes. Thus, the present research aimed to assess the antifungal and anti-biofilm activity of PCL-based constructs by the addition of antimicrobials, for instance, silver, against C. albicans and C. auris . The appearance of an inhibition halo around silver-functionalized PCL scaffolds for both C. albicans and C. auris was revealed, and a significant decrease in both adherent and planktonic yeasts further demonstrated the release of Ag + from the 3D constructs. Due to the combined antifungal, osteoproliferative, and biodegradable properties, PCL-based 3D scaffolds enriched with silver showed good potential for bone tissue engineering and offer a promising strategy as an ideal anti-adhesive and anti-biofilm tool for the reduction in prosthetic joints of infections caused by Candida spp. by using antimicrobial molecule-targeted delivery. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/5/2784; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/40c81a8848194a13b61ca0fd24169938 |
| DOI: | 10.3390/ijms25052784 |
| الاتاحة: | https://doi.org/10.3390/ijms25052784 https://doaj.org/article/40c81a8848194a13b61ca0fd24169938 |
| رقم الانضمام: | edsbas.5D6A6110 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25052784 |