Academic Journal
Thymostimulin versus placebo for palliative treatment of locally advanced or metastasised hepatocellular carcinoma: a phase III clinical trial.
| العنوان: | Thymostimulin versus placebo for palliative treatment of locally advanced or metastasised hepatocellular carcinoma: a phase III clinical trial. |
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| المؤلفون: | Dollinger, M.M., Lautenschlaeger, C., Lesske, J., Tannapfel, A., Wagner, A.D., Schoppmeyer, K., Nehls, O., Welker, M.W., Wiest, R., Fleig, W.E. |
| المساهمون: | AIO Hepatobiliary Study Group, Lesske, J., Dollinger, MM., Fleig, WE., Schoppmeyer, K., Mössner, J., Nehls, O., Gregor, M., Welker, MW., Zeuzem, S., Wiest, R., Schoelmerich, J., Hummel, F., Singer, M., Seufferlein, T., Adler, G., Mohr, L., Spangenberg, HC., Blum, H., Pohl, M., Schmiegel, W., Gog, C., Bechstein, W., Schaefer, C., Stange, E., Lammert, F., Matern, S. |
| المصدر: | Bmc Cancer, vol. 10, pp. 457 |
| سنة النشر: | 2010 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Carcinoma, Hepatocellular/drug therapy, Hepatocellular/secondary, Disease Progression, Double-Blind Method, Female, Follow-Up Studies, Humans, Interferon Inducers/therapeutic use, Liver Neoplasms/drug therapy, Liver Neoplasms/pathology, Male, Middle Aged, Neoplasm Staging, Palliative Care, Placebos, Prospective Studies, Survival Rate, Thymus Extracts/therapeutic use, Treatment Outcome, Young Adult |
| الوصف: | BACKGROUND: Thymostimulin is a thymic peptide fraction with immune-mediated cytotoxicity against hepatocellular carcinoma (HCC) in vitro and palliative efficacy in advanced HCC in two independent phase II trials. The aim of this study was to assess the efficacy of thymostimulin in a phase III trial. METHODS: The study was designed as a prospective randomised, placebo-controlled, double-blind, multicenter clinical phase III trial. Between 10/2002 and 03/2005, 135 patients with locally advanced or metastasised HCC (Karnofsky >or=60%/Child-Pugh |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/20735834; info:eu-repo/semantics/altIdentifier/eissn/1471-2407; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_B8BD021BE3A35; https://serval.unil.ch/notice/serval:BIB_B8BD021BE3A3; https://serval.unil.ch/resource/serval:BIB_B8BD021BE3A3.P001/REF.pdf |
| DOI: | 10.1186/1471-2407-10-457 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_B8BD021BE3A3 https://doi.org/10.1186/1471-2407-10-457 https://serval.unil.ch/resource/serval:BIB_B8BD021BE3A3.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_B8BD021BE3A35 |
| Rights: | info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimer |
| رقم الانضمام: | edsbas.5D300221 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1471-2407-10-457 |
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