Academic Journal
Controlled Study with Imidazole Carboxamide (DTIC), DTIC + Bacillus Calmette-Guérin (BCG), and DTIC + Corynebacterium Parvum in Advanced Malignant Melanoma
| العنوان: | Controlled Study with Imidazole Carboxamide (DTIC), DTIC + Bacillus Calmette-Guérin (BCG), and DTIC + Corynebacterium Parvum in Advanced Malignant Melanoma |
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| المؤلفون: | Veronesi, U., Aubert, C., Bajetta, E., Beretta, G., Bonadonna, G., Cascinelli, N., De Marsillac, J., Ikonopisov, R. L., Kiss, B., Krementz, T., Lejeune, F., Mechl, Z., Milton, G. W., Morabito, A., Mulder, P., Pawlicki, P., Priario, J., Rumke, P., Sertoli, R., Tomin, R., Trapeznikov, N., Wagner, R. |
| المصدر: | Tumori Journal ; volume 70, issue 1, page 41-48 ; ISSN 0300-8916 2038-2529 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 1984 |
| الوصف: | From 1976 to 1980, 377 randomized patients were entered in a multicentric study supported by the W.H.O. Melanoma Group. In this report, only 196 patients are considered for analysis: 31.6 % were excluded because of inadequate treatment or protocol violations. Three arms of treatment were compared: DTIC alone, DTIC plus bacillus Calmette-Guérin, and DTIC plus Corynebacterium parvum. No significant difference in terms of complete response plus partial response was detected among the three regimens. Twenty-five patients (12.7 %) responded with complete tumor regression, and 18 (9.3 %) with partial regression. Complete plus partial responses were thus achieved in 22 % of evaluable patients. Responders had a longer median survival than nonresponders. Overall median survival was 6 months. Brain metastases were detected in 17 % of the patients. Median time from the beginning of treatment to the diagnosis of CNS involvement was 4 months. There is no evidence that active aspecific immunotherapy added to DTIC increases the response rate in patients with disseminated disease. The toxic effects were acceptable, and no drug-related death was observed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/030089168407000107 |
| الاتاحة: | https://doi.org/10.1177/030089168407000107 https://journals.sagepub.com/doi/pdf/10.1177/030089168407000107 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.5D0F7D52 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/030089168407000107 |
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