Conference
Automated image analyses of cystic fibrosis transmembrane conductance regulation-dependent, β-adrenergically-evoked sweat secretion driven by iontophoresis
| العنوان: | Automated image analyses of cystic fibrosis transmembrane conductance regulation-dependent, β-adrenergically-evoked sweat secretion driven by iontophoresis |
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| المؤلفون: | Reynaerts, Audrey, vermeulen, francois, Melotti, paola, Gohy, Sophie, Frédérick, Raphaël, Nietert, m, Leal, Teresinha, ECFS Conference 2020 |
| المساهمون: | UCL - (SLuc) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Centre de référence pour la mucoviscidose, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology |
| المصدر: | Journal of Cystic Fibrosis, Vol. 19, no.S15, p. S15 (2020) |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2020 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| الوصف: | Automated image analyses of cystic fibrosis transmembrane conductance regulation-dependent, β-adrenergically-evoked sweat secretion driven by iontophoresis A. Reynaerts1 , F. Vermeulen2 , P. Melotti3 , S. Gohy4 , R. Frédérick5 , M. Nietert6 , T. Leal7 . 1 Université catholique de Louvain, Louvain Center for Toxicology and Applied Pharmacology, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium; 2 Université catholique de Louvain, Cystic Fibrosis Center, Leuven, Belgium; 3 Azienda Ospedaliera Universitaria Integrata, Cystic Fibrosis Center, Verona, Italy; 4 Université Catholique de Louvain, Cystic Fibrosis Center, Bruxelles, Belgium; 5 Université catholique de Louvain, Medicinal Chemistry, Louvain Drug Research Institute, Bruxelles, Belgium; 6 University of Goettingen, Institut fuer Medizinische Bioinformatik, Goettingen, Germany; 7 Université catholique de Louvain, Louvain Center for Toxicology and Applied Pharmacology, Institut de Recherche Expérimentale et Clinique, Bruxelles, Belgium Objectives: An image-based test allowing dissecting Cystic Fibrosis (CF) Transmembrane Conductance Regulator-independent and -dependent sweat secretionwas previously validated in small cohorts using intradermal injections and laborious operator-dependent image analysis. The test was reported to better define diagnosis, prognosis and efficacy of CF-directed therapies. The aim of this work is to evaluate, in larger cohorts, the automated analysis of images reflecting cholinergic or β-adrenergic stimulated sweat secretion obtained during a non-invasive version of the test. Methods: Cholinergically- or β-adrenergically-stimulated sweat secretion was obtained by iontophoresis of pilocarpine solution or by electroosmosis of solution with atropine, isoproterenol and aminophylline. Both solutions were conducted using Macroduct device (Wescor). Efficacy of drug delivery was previously evaluated by evaporimetry. Images of sweat droplets were recorded during cholinergic and β-adrenergic phases. A software was ... |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| تدمد: | 1569-1993 1873-5010 |
| Relation: | boreal:231348; http://hdl.handle.net/2078.1/231348; urn:ISSN:1569-1993; urn:EISSN:1873-5010 |
| DOI: | 10.1016/S1569-1993(20)30213-7 |
| الاتاحة: | http://hdl.handle.net/2078.1/231348 https://doi.org/10.1016/S1569-1993(20)30213-7 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5C9D0AD9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15691993 18735010 |
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| DOI: | 10.1016/S1569-1993(20)30213-7 |