Academic Journal
Hox genes in the adult skeleton: Novel functions beyond embryonic development
| العنوان: | Hox genes in the adult skeleton: Novel functions beyond embryonic development |
|---|---|
| المؤلفون: | Rux, Danielle R., Wellik, Deneen M. |
| المساهمون: | NIH |
| المصدر: | Developmental Dynamics ; volume 246, issue 4, page 310-317 ; ISSN 1058-8388 1097-0177 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Hox genes encode evolutionarily conserved transcription factors that control skeletal patterning in the developing embryo. They are expressed in regionally restricted domains and function to regulate the morphology of specific vertebral and long bone elements. Recent work has provided evidence that Hox genes continue to be regionally expressed in adult tissues. Fibroblasts cultured from adult tissues show broadly maintained Hox gene expression patterns. In the adult skeleton, Hox genes are expressed in progenitor‐enriched populations of mesenchymal stem/stromal cells (MSCs), and genetic loss‐of‐function analyses have provided evidence that Hox genes function during the fracture healing process. This review will highlight our current understanding of Hox expression in the adult animal and its function in skeletal regeneration. Developmental Dynamics 246:310–317, 2017 . © 2016 Wiley Periodicals, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/dvdy.24482 |
| الاتاحة: | http://dx.doi.org/10.1002/dvdy.24482 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdvdy.24482 https://onlinelibrary.wiley.com/doi/full/10.1002/dvdy.24482 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.5C73BA02 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/dvdy.24482 |
|---|