Academic Journal
Caveolin-1 Expression in Thyroid Neoplasia Spectrum: Comparison of Two Commercial Antibodies
| العنوان: | Caveolin-1 Expression in Thyroid Neoplasia Spectrum: Comparison of Two Commercial Antibodies |
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| المؤلفون: | Jelena Janković, Svetlana Paskaš, Ilona Marečko, Vesna Božić, Dubravka Cvejić, Svetlana Savin |
| المصدر: | Disease Markers, Vol 33, Iss 6, Pp 321-331 (2012) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2012 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | We evaluated caveolin-1 expression in the human thyroid neoplasia spectrum with the aim of examining differences in expression as detected by two anti-caveolin-1 antibodies, and secondly, to investigate the association of caveolin-1 expression levels with aggressive papillary thyroid carcinoma (PTC). Immunohistochemical staining using sc894 or AV09019 antibodies revealed that caveolin-1 was generally overexpressed in the PTC group as a whole (classical and follicular variant) when compared to peritumoral tissue (PT), while it was not detected in about half of follicular thyroid carcinoma (FTC) and majority of follicular adenomas (FTA). Caveolin-1 expression decreased in the following order: clPTC, fvPTC, FTC, PT and FTA. The diagnostic accuracy of AV09019 was better than that of sc894 for discriminating: FTA from FTC, FTA or FTC from the follicular variant of PTC, total PTC from nonmalignant tissue, and malignant tumors from nonmalignant tissue. Spearman's analysis revealed positive correlations of caveolin-1 expression and extrathyroidal invasion (p < 0.05) in PTC for both antibodies. Additionally, AV09019 antibody correlated caveolin-1 upregulation with pathological T status. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0278-0240 1875-8630 |
| Relation: | http://dx.doi.org/10.3233/DMA-2012-00934; https://doaj.org/toc/0278-0240; https://doaj.org/toc/1875-8630; https://doaj.org/article/c61df38d5820410fb33b978c2962bd5c |
| DOI: | 10.3233/DMA-2012-00934 |
| الاتاحة: | https://doi.org/10.3233/DMA-2012-00934 https://doaj.org/article/c61df38d5820410fb33b978c2962bd5c |
| رقم الانضمام: | edsbas.5C5C65A5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02780240 18758630 |
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| DOI: | 10.3233/DMA-2012-00934 |