التفاصيل البيبلوغرافية
| العنوان: |
Rabphilin-3A Drives Structural Modifications of Dendritic Spines Induced by Long-Term Potentiation |
| المؤلفون: |
Luca Franchini, Jennifer Stanic, Marta Barzasi, Elisa Zianni, Daniela Mauceri, Monica Diluca, Fabrizio Gardoni |
| المصدر: |
Cells; Volume 11; Issue 10; Pages: 1616 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
long-term potentiation, dendritic spines, NMDA receptors, AMPA receptors |
| الوصف: |
The interaction of Rabphilin-3A (Rph3A) with the NMDA receptor (NMDAR) in hippocampal neurons plays a pivotal role in the synaptic retention of this receptor. The formation of a Rph3A/NMDAR complex is needed for the induction of long-term potentiation and NMDAR-dependent hippocampal behaviors, such as spatial learning. Moreover, Rph3A can also interact with AMPA receptors (AMPARs) through the formation of a complex with myosin Va. Here, we used a confocal imaging approach to show that Rph3A overexpression in primary hippocampal neuronal cultures is sufficient to promote increased dendritic spine density. This morphological event is correlated with an increase in GluN2A-containing NMDARs at synaptic membranes and a decrease in the surface levels of GluA1-containing AMPARs. These molecular and morphological modifications of dendritic spines are sufficient to occlude the spine formation induced by long-term potentiation, but do not prevent the spine loss induced by long-term depression. Overall, our results demonstrate a key role for Rph3A in the modulation of structural synaptic plasticity at hippocampal synapses that correlates with its interactions with both NMDARs and AMPARs. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Cells of the Nervous System; https://dx.doi.org/10.3390/cells11101616 |
| DOI: |
10.3390/cells11101616 |
| الاتاحة: |
https://doi.org/10.3390/cells11101616 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.5C3C75F1 |
| قاعدة البيانات: |
BASE |