Academic Journal
Prevention of oxaliplatin-induced peripheral neuropathy by a polyamine-reduced diet--NEUROXAPOL: protocol of a prospective, randomised, controlled, single-blind and monocentric trial
| العنوان: | Prevention of oxaliplatin-induced peripheral neuropathy by a polyamine-reduced diet--NEUROXAPOL: protocol of a prospective, randomised, controlled, single-blind and monocentric trial |
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| المؤلفون: | Balayssac, David, Ferrier, Jérémy, Pereira, Bruno, Gillet, Brigitte, Petorin, Caroline, Vein, Julie, Libert, Frédéric, Eschalier, Alain, Pezet, Denis |
| المساهمون: | Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA) |
| المصدر: | ISSN: 2044-6055 ; BMJ Open ; https://hal.science/hal-04327774 ; BMJ Open, 2015, 5 (4), pp.e007479-e007479. ⟨10.1136/bmjopen-2014-007479⟩. |
| بيانات النشر: | HAL CCSD BMJ Publishing Group |
| سنة النشر: | 2015 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | MESH: Adult, MESH: Aged, MESH: Oxaliplatin, MESH: Peripheral Nervous System Diseases, MESH: Polyamines, MESH: Prospective Studies, MESH: Quality of Life, MESH: Single-Blind Method, MESH: Antineoplastic Agents, MESH: Diet Therapy, MESH: Female, MESH: Humans, MESH: Male, MESH: Middle Aged, MESH: Neurotoxicity Syndromes, MESH: Organoplatinum Compounds, [SDV]Life Sciences [q-bio] |
| الوصف: | Oxaliplatin remains the most widely used chemotherapeutic agent for treating advanced colorectal cancer but its efficacy is hampered by dose-limiting neurotoxicity manifested by a painful polyneuropathy. Oxaliplatin-induced peripheral neuropathy (OIPN) is characterised by acute and transient cold hyperaesthesia in the hours and days following oxaliplatin infusion (>90% of patients), but also by retarded chronic neuropathy due to the repetition of chemotherapy cycles (30-50% of patients). OIPN impairs the health-related quality of life (HRQOL) of patients and no preventive or curative strategies have as yet proven effective. A polyamine-reduced diet (PRD) has recently demonstrated its efficacy to prevent OIPN in animals without adverse effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/25833669; hal-04327774; https://hal.science/hal-04327774; PUBMED: 25833669; PUBMEDCENTRAL: PMC4390686 |
| DOI: | 10.1136/bmjopen-2014-007479 |
| الاتاحة: | https://hal.science/hal-04327774 https://doi.org/10.1136/bmjopen-2014-007479 |
| رقم الانضمام: | edsbas.5C2B38DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjopen-2014-007479 |
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