Academic Journal
Maternal HLA-C2 and 14bp insertion in HLA-G is associated with recurrent implantation failure after in vitro fertilization treatment
| العنوان: | Maternal HLA-C2 and 14bp insertion in HLA-G is associated with recurrent implantation failure after in vitro fertilization treatment |
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| المؤلفون: | Lashley, L. E. E. L. O., van der Westerlaken, L. A. J., Haasnoot, G. W., Drabbels, J. J. M., Spruyt-Gerritse, M. J., Scherjon, S. A., Claas, F. H. J. |
| المصدر: | Lashley , L E E L O , van der Westerlaken , L A J , Haasnoot , G W , Drabbels , J J M , Spruyt-Gerritse , M J , Scherjon , S A & Claas , F H J 2014 , ' Maternal HLA-C2 and 14bp insertion in HLA-G is associated with recurrent implantation failure after in vitro fertilization treatment ' , TISSUE ANTIGENS , vol. 84 , no. 6 , pp. 536-544 . https://doi.org/10.1111/tan.12452 |
| سنة النشر: | 2014 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | histocompatibility, HLA-C, HLA-G, in vitro fertilization, killer-cell immunoglobulin-like receptors, recurrent implantation failure, HUMAN-LEUKOCYTE ANTIGENS, INTRAUTERINE GROWTH-RETARDATION, IMMUNOGLOBULIN-LIKE RECEPTORS, REPRODUCTIVE FAILURE, G GENOTYPE, SPONTANEOUS-ABORTIONS, G EXPRESSION, T-CELLS, PREGNANCY, COUPLES |
| الوصف: | The major rate-limiting step in in vitro fertilization (IVF) success appears to be the implantation of the semi-allogeneic embryo into the maternal endometrium. To determine possible risk factors of recurrent failure of embryos to implant, we investigated immunogenetic determinants as level of human leukocyte antigen (HLA) histocompatibility, frequency of killer-cell immunoglobulin-like receptors (KIR) and HLA-C alleles and HLA-G polymorphism. We DNA typed women with recurrent implantation failure (RIF) and their partners for classical HLA Class I, HLA Class II, HLA-G and KIR alleles and compared these results with couples with successful embryo implantation after their first IVF and normal fertile couples. No association was found between RIF and the degree of histocompatibility between partners or sharing of a specific antigen. Also, no significant difference in KIR haplotype or combination of HLA-C group and KIR was observed. We did find a higher frequency of HLA-C2 and a higher frequency of 14base pair (bp) insertion in HLA-G in women with RIF. Therefore we conclude that the degree of histocompatibility between partners is not a determining factor for the occurrence of RIF. However, presence of the HLA-C2 allotype and the HLA-G allele with a 14bp insertion is a significant risk factor. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://research.rug.nl/en/publications/d11fe241-5a9e-4323-a955-97c447bc7e88 |
| DOI: | 10.1111/tan.12452 |
| الاتاحة: | https://hdl.handle.net/11370/d11fe241-5a9e-4323-a955-97c447bc7e88 https://research.rug.nl/en/publications/d11fe241-5a9e-4323-a955-97c447bc7e88 https://doi.org/10.1111/tan.12452 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.5C0D33CC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/tan.12452 |
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