التفاصيل البيبلوغرافية
| العنوان: |
Computational Processing and Quality Control of Hi-C, Capture Hi-C and Capture-C Data |
| المؤلفون: |
Peter Hansen, Michael Gargano, Jochen Hecht, Jonas Ibn-Salem, Guy Karlebach, Johannes T. Roehr, Peter N. Robinson |
| المصدر: |
Genes; Volume 10; Issue 7; Pages: 548 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
Hi-C, capture Hi-C, processing, quality control |
| جغرافية الموضوع: |
agris |
| الوصف: |
Hi-C, capture Hi-C (CHC) and Capture-C have contributed greatly to our present understanding of the three-dimensional organization of genomes in the context of transcriptional regulation by characterizing the roles of topological associated domains, enhancer promoter loops and other three-dimensional genomic interactions. The analysis is based on counts of chimeric read pairs that map to interacting regions of the genome. However, the processing and quality control presents a number of unique challenges. We review here the experimental and computational foundations and explain how the characteristics of restriction digests, sonication fragments and read pairs can be exploited to distinguish technical artefacts from valid read pairs originating from true chromatin interactions. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Technologies and Resources for Genetics; https://dx.doi.org/10.3390/genes10070548 |
| DOI: |
10.3390/genes10070548 |
| الاتاحة: |
https://doi.org/10.3390/genes10070548 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.5C0983F0 |
| قاعدة البيانات: |
BASE |