Academic Journal
Cerebrospinal fluid biomarkers in Alzheimer's disease: Diagnostic accuracy and prediction of dementia
| العنوان: | Cerebrospinal fluid biomarkers in Alzheimer's disease: Diagnostic accuracy and prediction of dementia |
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| المؤلفون: | Forlenza, Orestes V., Radanovic, Marcia, Talib, Leda L., Aprahamian, Ivan, Diniz, Breno S., Zetterberg, Henrik, Gattaz, Wagner F. |
| المساهمون: | Fundação de Amparo à Pesquisa de São Paulo, National Counsel of Technological and Scientific Development, Associação Beneficente Alzira Denise Hertzog da Silva, JNK Empreendimentos e Incorporações |
| المصدر: | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring ; volume 1, issue 4, page 455-463 ; ISSN 2352-8729 2352-8729 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Introduction Guidelines for the use of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease (AD) establish that each laboratory must use internally qualified cutoff values. We determined the concentrations of biomarkers that discriminate cases from controls and combinations that predict the progression to dementia in a Brazilian cohort. Methods Concentrations of amyloid‐beta peptide (Aβ 1–42 ), total tau (T‐tau), and 181 Thr‐phosphorylated‐tau (P‐tau) were determined in CSF samples from 184 older adults (68 mild cognitive impairment, 41 AD, 34 non‐AD cognitive impairment, and 41 controls) by the INNO‐BIA AlzBio3 assay. Results Cutoff values discriminating AD from controls are as follows: Aβ 1–42 : 416.0 pg/mL (sensitivity [SE]: 83%, specificity (SP): 70%); T‐tau: 76.7 pg/mL (SE: 82%, SP: 67%); P‐tau: 36.1 pg/mL (SE: 83%, SP: 49%); Aβ 1–42 /P‐tau <9.53 (SE: 88%, SP: 78%); and Aβ 1–42 /T‐tau <4.13 (SE: 80%; SP: 80%). Combining values Aβ 1–42 <416.5 pg/mL and Aβ 1–42 /P‐tau <9.5 best predicted the conversion in 2 years (Cox regression: hazard ratio 7.24 [2.09–25.06], P = .002, SE: 74%, Sp: 73%). Discussion Our findings are in line with most of the available evidence in this field; yet, our cutoff values are different from those derived from other laboratories. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.dadm.2015.09.003 |
| الاتاحة: | http://dx.doi.org/10.1016/j.dadm.2015.09.003 https://api.elsevier.com/content/article/PII:S2352872915000731?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S2352872915000731?httpAccept=text/plain https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.dadm.2015.09.003 https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.dadm.2015.09.003 https://onlinelibrary.wiley.com/doi/full-xml/10.1016/j.dadm.2015.09.003 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.5BE1DBF5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.dadm.2015.09.003 |
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