Academic Journal
High antibiotic resistance rates in Helicobacter pylori strains in Turkey over 20 years: implications for gastric disease treatment
| العنوان: | High antibiotic resistance rates in Helicobacter pylori strains in Turkey over 20 years: implications for gastric disease treatment |
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| المؤلفون: | Sarıkaya, Burak, Çetinkaya, Riza Aytaç, Özyiğitoğlu, Derya, Işık, Sinem Akkaya, Kaplan, Mustafa, Kırkık, Duygu, Görenek, Levent |
| المصدر: | European Journal of Gastroenterology & Hepatology ; volume 36, issue 5, page 545-553 ; ISSN 0954-691X |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2024 |
| الوصف: | Objective Helicobacter pylori (Hp) eradication therapy is crucial for preventing the development of gastritis, peptic ulcers, and gastric cancer. An increase in resistance against antibiotics used in the eradication of Hp is remarkable. This meta-analysis aims to examine the resistance rates of Hp strains isolated in Turkey over the last 20 years against clarithromycin (CLR), metronidazole (MTZ), levofloxacin (LVX), tetracycline (TET), and amoxicillin (AMX) antibiotics. Basic methods Literature search was carried out in electronic databases, by searching articles published in Turkish and English with the keywords ‘ helicobacter pylori ’ or ‘Hp’ and ‘antibiotic resistance’ and ‘Turkey’. That meta-analysis was carried out using random-effect model. First, the 20-year period data between 2002 and 2021 in Turkey were planned to be analyzed. As a second stage, the period between 2002 and 2011 was classified as Group 1, and the period between 2012 and 2021 as Group 2 for analysis, with the objective of revealing the 10-year temporal variation in antibiotic resistance rates. Main results In gastric biopsy specimens, 34 data from 29 studies were included in the analysis. Between 2002–2021, CLR resistance rate was 30.9% (95% CI: 25.9–36.2) in 2615 Hp strains. Specifically, in Group 1, the CLR resistance rate was 31% in 1912 strains, and in Group 2, it was 30.7% in 703 strains. The MTZ resistance rate was found to be 31.9% (95% CI: 19.8–45.4) in 789 strains, with rates of 21.5% in Group 1 and 46.6% in Group 2. The overall LVX resistance rate was 25.6%, with rates of 26.9% in Group 1 and 24.8% in Group 2. The 20-year TET resistance rate was 0.8%, with 1.50% in Group 1 and 0.2% in Group 2. The overall AMX resistance rate was 2.9%, 3.8% between 2002–2011, and 1.4% between 2012–2021. Principal conclusion Hp strains in Turkey exhibit high resistance rates due to frequent use of CLR, MTZ, and LVX antibiotics. However, a significant decrease has been observed in TET and AMX resistance to Hp in the last 10 years. Considering the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/meg.0000000000002733 |
| DOI: | 10.1097/MEG.0000000000002733 |
| الاتاحة: | http://dx.doi.org/10.1097/meg.0000000000002733 https://journals.lww.com/10.1097/MEG.0000000000002733 |
| رقم الانضمام: | edsbas.5BCE2FB2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/meg.0000000000002733 |
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