Academic Journal
Role of Cardiac Imaging in the Diagnosis of Immune Checkpoints Inhibitors Related Myocarditis
| العنوان: | Role of Cardiac Imaging in the Diagnosis of Immune Checkpoints Inhibitors Related Myocarditis |
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| المؤلفون: | Ederhy, Stéphane, Salem, Joe-Elie, Dercle, Laurent, Hasan, Abrar, Saqif, Chauvet-Droit, Marion, Nhan, Pascal, Ammari, Samy, Pinna, Bruno, Redheuil, Alban, Boussouar, Samia, Champiat, Stephane, Soulat-Dufour, Laurie, Cohen, Ariel |
| المساهمون: | CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pitié-Salpêtrière AP-HP, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP, Vanderbilt University Medical Center Nashville, Vanderbilt University Nashville, Institut Gustave Roussy (IGR), Albert Einstein College of Medicine New York, Département d'imagerie médicale Gustave Roussy, Institut de cardiologie CHU Pitié-Salpêtrière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale Paris (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département d’Innovation Thérapeutique et essais précoces Gustave Roussy (DITEP) |
| المصدر: | ISSN: 2234-943X ; Frontiers in Oncology ; https://hal.sorbonne-universite.fr/hal-03245855 ; Frontiers in Oncology, 2021, 11, ⟨10.3389/fonc.2021.640985⟩. |
| بيانات النشر: | HAL CCSD Frontiers |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | myocarditis, immune checkpoint inhibitor, cancer, cardiac magnetic resonance imaging, cardiotoxicity, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Immune checkpoint inhibitors (ICI) have constituted a paradigm shift in the management of patients with cancer. Their administration is associated with a new spectrum of immunerelated toxicities that can affect any organ. In patients treated with ICI, cardiovascular toxicities, particularly myocarditis, occur with a low incidence (<1%) but with a high fatality rate (30−50%). ICI-related myocarditis has been attributed to an immune infiltration, comprising of T-cells that are positive for CD3+, CD4+, CD8+, and macrophages that are positive for CD68. The diagnosis remains challenging and is made based on clinical syndrome, an electrocardiogram (ECG), biomarker data, and imaging criteria. In most clinical scenarios, endomyocardial biopsy plays a pivotal role in diagnosis, while cardiac magnetic resonance imaging (cMRI) has limitations that should be acknowledged. In this review, we discuss the role of medical imaging in optimizing the management of ICI related myocarditis, including diagnosis, prognostication, and treatment decisions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03245855; https://hal.sorbonne-universite.fr/hal-03245855; https://hal.sorbonne-universite.fr/hal-03245855/document; https://hal.sorbonne-universite.fr/hal-03245855/file/fonc-11-640985.pdf |
| DOI: | 10.3389/fonc.2021.640985 |
| الاتاحة: | https://hal.sorbonne-universite.fr/hal-03245855 https://hal.sorbonne-universite.fr/hal-03245855/document https://hal.sorbonne-universite.fr/hal-03245855/file/fonc-11-640985.pdf https://doi.org/10.3389/fonc.2021.640985 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.5BBAED4F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2021.640985 |
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