Academic Journal
ETS transcription factor ESE1/ELF3 orchestrates a positive feedback loop that constitutively activates NF-κB and drives prostate cancer progression
| العنوان: | ETS transcription factor ESE1/ELF3 orchestrates a positive feedback loop that constitutively activates NF-κB and drives prostate cancer progression |
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| المؤلفون: | Longoni, N., Sarti, M., Albino, D., Civenni, G., Malek, A., Ortelli, E., Pinton, S., Mello Grand, M., Ostano, P., D'Ambrosio, G., Garcia Escudero, R., Thalmann, G. N., Chiorino, G., Catapano, C. V., Carbone, G. M., SESSA, FAUSTO |
| المساهمون: | Longoni, N., Sarti, M., Albino, D., Civenni, G., Malek, A., Ortelli, E., Pinton, S., Mello Grand, M., Ostano, P., D'Ambrosio, G., Sessa, Fausto, Garcia Escudero, R., Thalmann, G. N., Chiorino, G., Catapano, C. V., Carbone, G. M. |
| سنة النشر: | 2013 |
| المجموعة: | IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
| الوصف: | Chromosomal translocations leading to deregulated expression of ETS transcription factors are frequent in prostate tumors. Here, we report a novel mechanism leading to oncogenic activation of the ETS factor ESE1/ELF3 in prostate tumors. ESE1/ELF3 was overexpressed in human primary and metastatic tumors. It mediated transforming phenotypes in vitro and in vivo and induced an inflammatory transcriptome with changes in relevant oncogenic pathways. ESE1/ELF3 was induced by interleukin (IL)-1β through NF-kB and was a crucial mediator of the phenotypic and transcriptional changes induced by IL-1β in prostate cancer cells. This linkage was mediated by interaction of ESE1/ELF3 with the NF-κB subunits p65 and p50, acting by enhancing their nuclear translocation and transcriptional activity and by inducing p50 transcription. Supporting these findings, gene expression profiling revealed an enrichment of NF-kB effector functions in prostate cancer cells or tumors expressing high levels of ESE1/ELF3. We observed concordant upregulation of ESE1/ELF3 and NF-κB in human prostate tumors that was associated with adverse prognosis. Collectively, our results define an important new mechanistic link between inflammatory signaling and the progression of prostate cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/23687337; info:eu-repo/semantics/altIdentifier/wos/WOS:000321823600034; volume:73; issue:14; firstpage:4533; lastpage:4547; numberofpages:15; journal:CANCER RESEARCH; http://hdl.handle.net/11383/2011922; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84880894958 |
| DOI: | 10.1158/0008-5472.CAN-12-4537 |
| الاتاحة: | http://hdl.handle.net/11383/2011922 https://doi.org/10.1158/0008-5472.CAN-12-4537 |
| رقم الانضمام: | edsbas.5B9EF03C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/0008-5472.CAN-12-4537 |
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