Peroxisome proliferator‐activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages

التفاصيل البيبلوغرافية
العنوان:	Peroxisome proliferator‐activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages
المؤلفون:	Gbaguidi, F.G, Chinetti, G, Milosavljevic, D, Teissier, E, Chapman, J, Olivecrona, G, Fruchart, J.C, Griglio, S, Fruchart-Najib, J, Staels, B
المصدر:	FEBS Letters ; volume 512, issue 1-3, page 85-90 ; ISSN 0014-5793 1873-3468
بيانات النشر:	Wiley
سنة النشر:	2002
المجموعة:	Wiley Online Library (Open Access Articles via Crossref)
الوصف:	Lipoprotein lipase (LPL) acts independently of its function as triglyceride hydrolase by stimulating macrophage binding and uptake of native, oxidized and glycated LDL. Peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors expressed in monocyte/macrophages, where they control cholesterol homeostasis. Here we study the role of PPARs in the regulation of LPL expression and activity in human monocytes and macrophages. Incubation of human monocytes or macrophages with PPARα or PPARγ ligands increases LPL mRNA and intracellular protein levels. By contrast, PPAR activators decrease secreted LPL mass and enzyme activity in differentiated macrophages. These actions of PPAR activators are associated with a reduced uptake of glycated LDL and could influence atherosclerosis development associated with diabetes.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1016/s0014-5793(02)02223-8
DOI:	10.1016/S0014-5793%2802%2902223-8
الاتاحة:	http://dx.doi.org/10.1016/s0014-5793(02)02223-8 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(02)02223-8 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2802%2902223-8
Rights:	http://onlinelibrary.wiley.com/termsAndConditions#vor
رقم الانضمام:	edsbas.5B9B0B71
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1016/s0014-5793(02)02223-8