Academic Journal
Effect of regular exercise training on platelet function in patients with cardiovascular disease and healthy individuals:A systematic review
| العنوان: | Effect of regular exercise training on platelet function in patients with cardiovascular disease and healthy individuals:A systematic review |
|---|---|
| المؤلفون: | Kristiansen, Jacobina, Grove, Erik L, Pedersen, Oliver Buchhave, Kristensen, Steen D, Hvas, Anne-Mette |
| المصدر: | Kristiansen , J , Grove , E L , Pedersen , O B , Kristensen , S D & Hvas , A-M 2023 , ' Effect of regular exercise training on platelet function in patients with cardiovascular disease and healthy individuals : A systematic review ' , Thrombosis Research , vol. 231 , pp. 223-235 . https://doi.org/10.1016/j.thromres.2022.12.017 |
| سنة النشر: | 2023 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Cardiovascular disease, Exercise, Platelet activation, Platelet aggregation, Platelet function test, Platelets, P-Selectin, Humans, Blood Platelets, Cardiovascular Diseases/therapy |
| الوصف: | INTRODUCTION: Regular exercise training is essential in prevention and treatment of cardiovascular disease (CVD), yet the beneficial effects of exercise remain only partly explained. Platelets play a key role in CVD and may be affected by regular exercise training. We aimed to systematically summarise studies investigating the effect of regular exercise training on platelet function in patients with CVD and in healthy individuals. METHODS: Studies were identified by PubMed, Embase and Web of Science May 16, 2022. We selected studies investigating markers of platelet function in relation to regular exercise training in patients with CVD and in healthy individuals. Regular exercise was defined as exercise training for four weeks or more. RESULTS: Of the included studies, 11 investigated patients with CVD and 29 were on healthy individuals. Studies were heterogeneous regarding design, study population and methodology, and the results were ambiguous. In total, 52 different markers of platelet function were investigated with platelet aggregation, soluble P-selectin, and thromboxane B 2 (TXB 2) as the most frequently examined. When evaluating between-group changes after regular exercise, two studies found a reduced platelet aggregation in the exercise group whilst three studies did not find a difference between groups. With respect to TXB 2, three studies reported a reduction and two studies an increase in the exercise group. There were no between-group differences in the seven studies examining soluble P-selectin. CONCLUSION: Regular exercise training has no clear impact on platelet function in patients with CVD or healthy individuals. PROSPERO REGISTRATION: CRD42022350539. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://pure.au.dk/portal/en/publications/a91b7331-6764-4f90-b24e-c943aed76fc0 |
| DOI: | 10.1016/j.thromres.2022.12.017 |
| الاتاحة: | https://pure.au.dk/portal/en/publications/a91b7331-6764-4f90-b24e-c943aed76fc0 https://doi.org/10.1016/j.thromres.2022.12.017 http://www.scopus.com/inward/record.url?scp=85145679201&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5B8FCC9E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.thromres.2022.12.017 |
|---|