Academic Journal
Innate Immune Cells during Machine Perfusion of Liver Grafts—The Janus Face of Hepatic Macrophages
| العنوان: | Innate Immune Cells during Machine Perfusion of Liver Grafts—The Janus Face of Hepatic Macrophages |
|---|---|
| المؤلفون: | Roushansarai, N.S. (Nicola), Pascher, A. (Andreas), Becker, F. (Felix) |
| المساهمون: | Universitäts- und Landesbibliothek Münster |
| سنة النشر: | 2023 |
| المجموعة: | Münster University (WWU): miami |
| مصطلحات موضوعية: | machine perfusion, normothermic, hypothermic, ischemia–reperfusion injury, liver transplantation, clinical trials, ddc:610, info:eu-repo/classification/ddc/610, Medicine and health |
| الوصف: | Machine perfusion is an emerging technology in the field of liver transplantation. While machine perfusion has now been implemented in clinical routine throughout transplant centers around the world, a debate has arisen regarding its concurrent effect on the complex hepatic immune system during perfusion. Currently, our understanding of the perfusion-elicited processes involving innate immune cells remains incomplete. Hepatic macrophages (Kupffer cells) represent a special subset of hepatic immune cells with a dual pro-inflammatory, as well as a pro-resolving and anti-inflammatory, role in the sequence of ischemia–reperfusion injury. The purpose of this review is to provide an overview of the current data regarding the immunomodulatory role of machine perfusion and to emphasize the importance of macrophages for hepatic ischemia–reperfusion injury. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.17879/19958652681 |
| الاتاحة: | https://nbn-resolving.org/urn:nbn:de:hbz:6-79948499416 https://doi.org/10.17879/19958652681 https://miami.uni-muenster.de/Record/5958e593-bf25-4d36-aade-5b1a4c5dfce8 https://repositorium.uni-muenster.de/transfer/miami/5958e593-bf25-4d36-aade-5b1a4c5dfce8 |
| Rights: | CC BY 4.0 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5B863B40 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17879/19958652681 |
|---|