Academic Journal
Genetic and environmental contributions for the relationship between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma
| العنوان: | Genetic and environmental contributions for the relationship between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma |
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| المؤلفون: | da Silva, Adriana M., Falcão, Michelle M. L., Freitas, Valéria S., Vieira, Alexandre R. |
| المساهمون: | Fundação de Amparo à Pesquisa do Estado da Bahia, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| المصدر: | Head & Neck ; volume 46, issue 6, page 1417-1427 ; ISSN 1043-3074 1097-0347 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background To investigate the association between tooth loss and oral potentially malignant disorders and oral squamous cell carcinoma, focusing on epidemiological factors and genetic variants. Methods Case–control study, including histologically confirmed oral potentially malignant disorders and oral squamous cell carcinoma cases and healthy controls. Unadjusted and adjusted odds ratios for this association were calculated. Single‐nucleotides polymorphisms were tested for individuals with and without missing teeth. Results Case individuals were more edentulous while controls had fewer missing teeth ( p = 0.006). There was an increased risk for the outcomes associated with edentulism (OR = 6.95, p = 0.000), even after adjustments for educational level (OR = 4.7, p = 0.034) and smoking habits (OR = 5.01, p = 0.022). Among individuals with tooth loss, rs1533767 ( WNT11 ), rs3923087, and rs11867417 ( AXIN2) were associated with the outcomes (OR = 1.67, p = 0.03, OR = 0.53, p = 0.05, and OR = 0.42, p = 0.00, respectively). Conclusions Tooth loss could increase the risk for oral potentially malignant disorders and oral squamous cell carcinoma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/hed.27648 |
| الاتاحة: | https://doi.org/10.1002/hed.27648 https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27648 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.5B7BD5E3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/hed.27648 |
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