Academic Journal
Multitier mechanics control stromal adaptations in swelling lymph nodes
| العنوان: | Multitier mechanics control stromal adaptations in swelling lymph nodes |
|---|---|
| المؤلفون: | Assen, Frank P, Abe, Jun, Hons, Miroslav, Hauschild, Robert, Shamipour, Shayan, Kaufmann, Walter, Costanzo, Tommaso, Krens, Gabriel, Brown, Markus, Ludewig, Burkhard, Hippenmeyer, Simon, Heisenberg, Carl-Philipp J, Weninger, Wolfgang, Hannezo, Edouard B, Luther, Sanjiv A., Stein, Jens V., Sixt, Michael K |
| المصدر: | Assen FP, Abe J, Hons M, et al. Multitier mechanics control stromal adaptations in swelling lymph nodes. Nature Immunology . 2022;23:1246-1255. doi: 10.1038/s41590-022-01257-4 |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2022 |
| المجموعة: | IST Austria Research Explorer (Institute of Science and Technology) |
| مصطلحات موضوعية: | ddc:570 |
| الوصف: | Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale. We identified lymphocyte trapping by influx and proliferation as drivers of an outward pressure force, causing fibroblastic reticular cells of the T-zone (TRCs) and their associated conduits to stretch. After an initial phase of relaxation, TRCs sensed the resulting strain through cell matrix adhesions, which coordinated local growth and remodeling of the stromal network. While the expanded TRC network readopted its typical configuration, a massive fibrotic reaction of the organ capsule set in and countered further organ expansion. Thus, different fibroblast populations mechanically control LN swelling in a multitier fashion. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/issn/1529-2908; info:eu-repo/semantics/altIdentifier/issn/1529-2916; info:eu-repo/semantics/altIdentifier/wos/000822975900002; info:eu-repo/grantAgreement/EC/H2020/724373; https://research-explorer.ista.ac.at/record/9794; https://research-explorer.ista.ac.at/download/9794/11642 |
| الاتاحة: | https://research-explorer.ista.ac.at/record/9794 https://research-explorer.ista.ac.at/download/9794/11642 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5B652D1A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |