Academic Journal
Global longitudinal strain and plasma biomarkers for prognosis in heart failure complicated by diabetes: a prospective observational study
| العنوان: | Global longitudinal strain and plasma biomarkers for prognosis in heart failure complicated by diabetes: a prospective observational study |
|---|---|
| المؤلفون: | Nithin R. Iyer, Siew-Pang Chan, Oi Wah Liew, Jenny P.C. Chong, Jennifer A. Bryant, Thu-Thao Le, Chanchal Chandramouli, Patrick J. Cozzone, Frank Eisenhaber, Roger Foo, A. Mark Richards, Carolyn S.P. Lam, Martin Ugander, Calvin W-L. Chin, on behalf of the ATTRaCT investigators |
| المصدر: | BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-13 (2024) |
| بيانات النشر: | BMC |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Magnetic resonance imaging, Heart failure, Global longitudinal strain, Biomarkers, Prognosis, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background Heart failure (HF) and diabetes are associated with increased incidence and worse prognosis of each other. The prognostic value of global longitudinal strain (GLS) measured by cardiovascular magnetic resonance (CMR) has not been established in HF patients with diabetes. Methods In this prospective, observational study, consecutive patients (n = 315) with HF underwent CMR at 3T, including GLS, late gadolinium enhancement (LGE), native T1, and extracellular volume fraction (ECV) mapping. Plasma biomarker concentrations were measured including: N-terminal pro B-type natriuretic peptide(NT-proBNP), high-sensitivity troponin T(hs-TnT), growth differentiation factor 15(GDF-15), soluble ST2(sST2), and galectin 3(Gal-3). The primary outcome was a composite of all-cause mortality or HF hospitalisation. Results Compared to those without diabetes (n = 156), the diabetes group (n = 159) had a higher LGE prevalence (76 vs. 60%, p < 0.05), higher T1 (1285±42 vs. 1269±42ms, p < 0.001), and higher ECV (30.5±3.5 vs. 28.8±4.1%, p < 0.001). The diabetes group had higher NT-pro-BNP, hs-TnT, GDF-15, sST2, and Gal-3. Diabetes conferred worse prognosis (hazard ratio (HR) 2.33 [95% confidence interval (CI) 1.43–3.79], p < 0.001). In multivariable Cox regression analysis including clinical markers and plasma biomarkers, sST2 alone remained independently associated with the primary outcome (HR per 1 ng/mL 1.04 [95% CI 1.02–1.07], p = 0.001). In multivariable Cox regression models in the diabetes group, both GLS and sST2 remained prognostic (GLS: HR 1.12 [95% CI 1.03–1.21], p = 0.01; sST2: HR per 1 ng/mL 1.03 [95% CI 1.00-1.06], p = 0.02). Conclusions Compared to HF patients without diabetes, those with diabetes have worse plasma and CMR markers of fibrosis and a more adverse prognosis. GLS by CMR is a powerful and independent prognostic marker in HF patients with diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2261 |
| Relation: | https://doi.org/10.1186/s12872-024-03810-5; https://doaj.org/toc/1471-2261; https://doaj.org/article/50c9a119501141aaba899532f7f7c77d |
| DOI: | 10.1186/s12872-024-03810-5 |
| الاتاحة: | https://doi.org/10.1186/s12872-024-03810-5 https://doaj.org/article/50c9a119501141aaba899532f7f7c77d |
| رقم الانضمام: | edsbas.5B60D43E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712261 |
|---|---|
| DOI: | 10.1186/s12872-024-03810-5 |