Academic Journal
Long-term Outcomes of Paediatric Patients Admitted With Acute Severe Colitis- A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN
| العنوان: | Long-term Outcomes of Paediatric Patients Admitted With Acute Severe Colitis- A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN |
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| المؤلفون: | Krauthammer A., Tzivinikos C., Assa A., Miele E., Strisciuglio C., Urlep D., Serban E. D., Singh A., Winter H. S., Russell R. K., Hojsak I., Malham M., Navas-Lopez V. M., Croft N. M., Lee H. M., Ledder O., Shamasneh I., Hussey S., Huynh H. Q., Wine E., Shah N., Sladek M., de Meij T. G., Romano C., Dipasquale V., Lionetti P., Afzal N. A., Aloi M., Lee K., Martin-de-Carpi J., Yerushalmy-Feler A., Subramanian S., Weiss B., Shouval D. S. |
| المساهمون: | Krauthammer, A., Tzivinikos, C., Assa, A., Miele, E., Strisciuglio, C., Urlep, D., Serban, E. D., Singh, A., Winter, H. S., Russell, R. K., Hojsak, I., Malham, M., Navas-Lopez, V. M., Croft, N. M., Lee, H. M., Ledder, O., Shamasneh, I., Hussey, S., Huynh, H. Q., Wine, E., Shah, N., Sladek, M., de Meij, T. G., Romano, C., Dipasquale, V., Lionetti, P., Afzal, N. A., Aloi, M., Lee, K., Martin-de-Carpi, J., Yerushalmy-Feler, A., Subramanian, S., Weiss, B., Shouval, D. S. |
| بيانات النشر: | NLM (Medline) |
| سنة النشر: | 2019 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | acute severe coliti, anti-TNFa, biologic, colectomy, UC |
| الوصف: | BACKGROUND AND AIM: Acute severe colitis [ASC] is associated with significant morbidity in paediatric patients with ulcerative colitis [UC]. Most outcome studies in ASC since tumour necrosis factor alpha [TNFα] antagonists became available have focused on the first year after admission. The aim of this study was to characterise the longer-term outcomes of paediatric patients admitted with ASC. METHODS: This retrospective study was conducted in 25 centres across Europe and North America. Data on patients with UC aged <18 years, admitted with ASC (defined as paediatric ulcerative colitis activity index [PUCAI] score ≥65) between 2009 and 2011, were collected at discharge and 1, 3 and 5 years after admission. The primary outcome was colectomy-free rates at each time point. RESULTS: Of the 141 patients admitted with ASC, 137 [97.1%] were treated with intravenous corticosteroids. Thirty-one [22.6%] patients were escalated to second-line therapy, mainly to infliximab. Sixteen patients [11.3%] underwent colectomy before discharge. Long-term follow-up showed colectomy-free rates were 71.3%, 66.4% and 63.6% at 1, 3 and 5 years after initial ASC admission, respectively, and were similar across different age groups. Sub-analysis of colectomy rates in patients with new-onset disease [42.5% of the cohort] yielded similar results. In a multivariate analysis, use of oral steroids in the 3 months before admission, erythrocyte sedimentation rate >70 mm/h, and albumin <2.5 g/dL, were significantly associated with 5-year colectomy risk. CONCLUSIONS: High colectomy rates were demonstrated in paediatric UC patients admitted with ASC. Additional studies are required to determine whether intensification of anti-TNFα treatment, close therapeutic drug monitoring, and use of new drugs alter this outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000504927200006; volume:13; issue:12; firstpage:1518; lastpage:1526; numberofpages:9; journal:JOURNAL OF CROHN'S AND COLITIS; http://hdl.handle.net/11573/1347405; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85074824816 |
| DOI: | 10.1093/ecco-jcc/jjz092 |
| الاتاحة: | http://hdl.handle.net/11573/1347405 https://doi.org/10.1093/ecco-jcc/jjz092 |
| رقم الانضمام: | edsbas.5B2C73A4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ecco-jcc/jjz092 |
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