Academic Journal
The key role of corneocytes in pityrosporoses.
| العنوان: | The key role of corneocytes in pityrosporoses. |
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| المؤلفون: | Pierard, Gérald, Xhauflaire, Emmanuelle, Pierard, Claudine |
| المصدر: | Dermatology, 212 (1), 23-6 (2006) |
| بيانات النشر: | S. Karger |
| سنة النشر: | 2006 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Dermatitis, Seborrheic/drug therapy/microbiology/pathology, Dermatomycoses/drug therapy/microbiology/pathology, Hair Preparations/pharmacology, Humans, Keratinocytes/drug effects/microbiology/pathology, Malassezia/drug effects/growth & development/ultrastructure, Microscopy, Electron, Scanning, Skin/drug effects/microbiology/pathology, Human health sciences, Dermatology, Sciences de la santé humaine, Dermatologie |
| الوصف: | peer reviewed ; Pityrosporoses encompass various Malassezia-driven conditions. Dandruff and seborrheic dermatitis are members of this family of disorders. Their precise pathomechanisms have not been completely elucidated so far. This review focuses on the role of corneocytes in these disorders. Malassezia yeasts are not evenly distributed at the surface of the stratum corneum. Rather, they are clumped on some corneocytes while other corneocytes in their vicinity are almost free of these microorganisms. The corneocytes heavily coated by yeasts suggest a cell-related defect in the mechanisms controlling the skin biocene including the natural antimicrobial peptides and nitric oxide. Most environmental factors influencing pityrosporoses indeed affect the natural human defenses against certain microorganisms. We frame as a hypothesis that the primary defect in some Malassezia-driven disorders resides in the corneocytes and their precursor keratinocytes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1018-8665 1421-9832 |
| Relation: | urn:issn:1018-8665; urn:issn:1421-9832; https://orbi.uliege.be/handle/2268/6065; info:hdl:2268/6065; info:pmid:16319469 |
| DOI: | 10.1159/000089017 |
| الاتاحة: | https://orbi.uliege.be/handle/2268/6065 https://doi.org/10.1159/000089017 |
| Rights: | restricted access ; http://purl.org/coar/access_right/c_16ec ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.5AE46C1B |
| قاعدة البيانات: | BASE |
| تدمد: | 10188665 14219832 |
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| DOI: | 10.1159/000089017 |