التفاصيل البيبلوغرافية
| العنوان: |
Toll-like receptor-4 expression and oxidative stress in ocular rosacea |
| المؤلفون: |
Yeşilırmak, Nilüfer, Kurt, Büşra, Fatsa, Tuğba, Yüzbaşıoğlu, Sema, Zhao, Min, Hoşbul, Tuğrul, Bourges, Jean-Louis, Behar-Cohen, Francine, Bukan, Neslihan |
| سنة النشر: |
2023 |
| الوصف: |
Purpose: To investigate systemic and ocular toll-like receptor (TLR)-4 expression and its association with oxidativestress markers in ocular rosacea (OR)Methods: This prospective study included 40 patients with rosacea with ocular involvement and 20 healthy volunteers.Tear break-up time (TBUT), Schirmer test, meibomoscore, and ocular surface disease index (OSDI) scores were estimated for all participants. TLR-4 expression in conjunctival epithelium and peripheral blood mononuclear cells wasquantified using real-time polymerase chain reaction (RT-PCR). In the tears and serum samples of all participants,antioxidant status (TAS), total oxidant status (TOS), and arylesterase (ARE) activation levels were measured using afully automated spectrophotometric method, and the oxidative stress index (OSI) was calculated.Results: TLR-4 expression levels and oxidative stress status (TOS and OSI values) were significantly higher (p < 0.01),and antioxidant status (TAS and ARE values) were significantly lower (p < 0.01) in both ocular and blood samples ofpatients with OR compared with those in controls. A significant positive correlation was found between the ocular andblood values in all parameters (p < 0.05). According to the clinical associations of these results, we found negative correlations between TLR-4, OSI, and TBUT and between TLR-4 and Schirmer, whereas a positive correlation was observedbetween TLR-4, OSI, and meiboscore and between TLR-4, OSI, and OSDI (p < 0.05). No correlation was found betweenthe OSI and Schirmer results (p = 0.92).Conclusions: TLR-4 and oxidative stress both play important roles in OR pathophysiology and are closely related toclinical findings. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
606a0759-1f9b-46cb-a82e-e0d10ba9e36f; https://avesis.gazi.edu.tr/publication/details/606a0759-1f9b-46cb-a82e-e0d10ba9e36f/oai |
| الاتاحة: |
https://avesis.gazi.edu.tr/publication/details/606a0759-1f9b-46cb-a82e-e0d10ba9e36f/oai |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.5ADD526 |
| قاعدة البيانات: |
BASE |