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Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids

التفاصيل البيبلوغرافية
العنوان: Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids
المؤلفون: Sayeda Yasmin-Karim, Michele Moreau, Romy Mueller, Neeharika Sinha, Raymond Dabney, Allen Herman, Wilfred Ngwa
المصدر: Frontiers in Oncology, Vol 8 (2018)
بيانات النشر: Frontiers Media S.A.
سنة النشر: 2018
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: radiotherapy, cannabinoids or endocannabinoids, biomaterials, cancer, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could better leverage these effects in clinical translation. This study explores the potential of combination approaches employing CBDs with radiotherapy (RT) or smart biomaterials toward enhancing therapeutic efficacy during treatment of pancreatic and lung cancers. In in vitro studies, clonogenic assay results showed greater effective tumor cell killing, when combining CBDs and RT. Meanwhile, in vivo study results revealed major increase in survival when employing smart biomaterials for sustained delivery of CBDs to tumor cells. The significance of these findings, considerations for further research, and viable roadmap to clinical translation are discussed.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2234-943X
Relation: http://journal.frontiersin.org/article/10.3389/fonc.2018.00114/full; https://doaj.org/toc/2234-943X; https://doaj.org/article/fa0b31bf48e447d0852f380646065396
DOI: 10.3389/fonc.2018.00114
الاتاحة: https://doi.org/10.3389/fonc.2018.00114
https://doaj.org/article/fa0b31bf48e447d0852f380646065396
رقم الانضمام: edsbas.5AD69293
قاعدة البيانات: BASE
الوصف
تدمد:2234943X
DOI:10.3389/fonc.2018.00114