Academic Journal
CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children.
| العنوان: | CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children. |
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| المؤلفون: | Tanvi S Sharma, Jane Hughes, Amarylis Murillo, Joanne Riley, Andreia Soares, Francesca Little, Charles D Mitchell, Willem A Hanekom |
| المصدر: | PLoS ONE, Vol 3, Iss 12, p e3986 (2008) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2008 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Initiation and modification of antiretroviral therapy in HIV-infected children depend on viral load and CD4+ T-cell count. However, these surrogates have limitations, and complementary immunological markers to assess therapeutic response are needed. Our aim was to evaluate CD8+ T-cell expression of CD127 as a marker of disease status in HIV-infected children, based on adult data suggesting its usefulness. We hypothesized that CD127 expression on CD8+ T-cells is lower in children with more advanced disease.In a cross-sectional evaluation, we used flow cytometry to measure CD127+ expression on CD8+ T-cells in whole blood from HIV-infected children with varying disease status. This was compared with expression of CD38 on this subset, currently used in clinical practice as a marker of disease status.51 HIV-infected children were enrolled. There was a strong positive correlation between CD127 expression on CD8+ T-cells and CD4+ T-cell count, and height and weight z-scores, and a strong negative correlation between CD127 expression and viral load. In contrast, we found no association between CD38 expression and these disease status markers.CD8+ T-cell CD127 expression is significantly higher in children with better HIV disease control, and may have a role as an immunologic indicator of disease status. Longitudinal studies are needed to determine the utility of this marker as a potential indicator of HIV disease progression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC2599882?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/7ef3a070e185417ebb6162ed05b47377 |
| DOI: | 10.1371/journal.pone.0003986 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0003986 https://doaj.org/article/7ef3a070e185417ebb6162ed05b47377 |
| رقم الانضمام: | edsbas.5ABE2FAE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0003986 |