Academic Journal
MRI DTI and PDFF as Biomarkers for Lower Motor Neuron Degeneration in ALS
| العنوان: | MRI DTI and PDFF as Biomarkers for Lower Motor Neuron Degeneration in ALS |
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| المؤلفون: | Thorsten Lichtenstein, Alina Sprenger, Kilian Weiss, Nils Große Hokamp, David Maintz, Marc Schlamann, Gereon R. Fink, Helmar C. Lehmann, Tobias D. Henning |
| المصدر: | Frontiers in Neuroscience, Vol 15 (2021) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | amyotrophic lateral sclerosis, diffusion tensor imaging, proton density fat fraction, neurodegeneration, motor neuron disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | ObjectiveTo evaluate the utility of nerve magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and muscle MRI multi-echo Dixon for assessing lower motor neuron (LMN) degeneration in amyotrophic lateral sclerosis (ALS).MethodsIn this prospective observational cohort study, 14 patients with ALS and 13 healthy controls underwent a multiparametric MRI protocol, including DTI of the sciatic nerve and assessment of muscle proton density fat fraction of the biceps femoris and the quadriceps femoris muscles by a multi-echo Dixon sequence.ResultsIn ALS patients, mean fractional anisotropy values of the sciatic nerve were significantly lower than those of healthy controls. The quadriceps femoris, but not the biceps femoris muscle, showed significantly higher intramuscular fat fractions in ALS.InterpretationOur study provides evidence that multiparametric MRI protocols might help estimate structural nerve damage and neurogenic muscle changes in ALS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1662-453X |
| Relation: | https://www.frontiersin.org/articles/10.3389/fnins.2021.682126/full; https://doaj.org/toc/1662-453X; https://doaj.org/article/0bd1b8bd9a9d4aa8afba993e1cc50129 |
| DOI: | 10.3389/fnins.2021.682126 |
| الاتاحة: | https://doi.org/10.3389/fnins.2021.682126 https://doaj.org/article/0bd1b8bd9a9d4aa8afba993e1cc50129 |
| رقم الانضمام: | edsbas.5A98AB19 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1662453X |
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| DOI: | 10.3389/fnins.2021.682126 |