Academic Journal
Cocaine-induced midline destruction
| العنوان: | Cocaine-induced midline destruction |
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| المؤلفون: | Ide, Veerle, Henckaerts, Liesbet, Vanbrabant, Peter, Vanderschueren, Steven |
| المصدر: | Oxford Medical Case Reports ; volume 2021, issue 2 ; ISSN 2053-8855 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Infectious Diseases, Microbiology, Parasitology |
| الوصف: | In patients presenting with nasal septum perforation, the differential diagnosis between ANCA-associated vasculitis and cocaine-induced midline destruction (CIMD) can be challenging. We describe the case of a 28-year old man who presented with a nasal septum perforation. He admitted the use of cocaine and showed no other symptoms of systemic inflammation. Perinuclear anti-neutrophilic cytoplasmatic antibodies (p-ANCAs) came back positive, as did anti-proteinase 3-antibodies. Further testing revealed antibodies to human neutrophil elastase (HNE), typically found in CIMD but rarely in ANCA-associated vasculitis. The combination of an atypical ANCA-pattern and the detection of HNE-antibodies led to the diagnosis of CIMD. In conclusion, HNE antibodies can be used to distinguish between CIMD and ANCA-associated vasculitis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/omcr/omaa135 |
| الاتاحة: | http://dx.doi.org/10.1093/omcr/omaa135 http://academic.oup.com/omcr/article-pdf/2021/2/omaa135/36263499/omaa135.pdf |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.5A8FD193 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/omcr/omaa135 |
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