Academic Journal
Characteristics of Type 1 Diabetes Among Patients Carrying the Protective HLA‐ DQB1*06:02 Allele
| العنوان: | Characteristics of Type 1 Diabetes Among Patients Carrying the Protective HLA‐ DQB1*06:02 Allele |
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| المؤلفون: | Taka, Antti‐Mathias, Härkönen, Taina, Vähäsalo, Paula, Vatanen, Tommi, Lempainen, Johanna, Veijola, Riitta, Turtinen, Maaret, Ilonen, Jorma, Knip, Mikael |
| المساهمون: | Lastentautien Tutkimussäätiö, Medicinska Understödsföreningen Liv och Hälsa, Finska Läkaresällskapet |
| المصدر: | HLA ; volume 104, issue 5 ; ISSN 2059-2302 2059-2310 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | We set out to examine in an observational study characteristics of type 1 diabetes at the time of diagnosis among paediatric patients carrying the protective HLA class II DQB1*06:02 allele. We compared characteristics of type 1 diabetes among 5530 Finnish children aged 0–14 years diagnosed between 2003 and 2018. Seventy‐five children with type 1 diabetes carried the DQB1*06:02 allele. The carriers of DQB1*06:02 allele were compared to all children with type 1 diabetes without this allele and those with a high‐risk genotype. We also analysed, how does the genotype of a high‐risk haplotype paired with DQB1*06:02 affect the phenotype of patients with newly diagnosed type 1 diabetes. Carriers of the DQB1*06:02 allele were diagnosed at an older age than those with any other HLA class II genotype ( p = 0.003) or the high‐risk genotype ( p < 0.001). After adjusting the results for age and sex, no significant differences in clinical markers were observed. Glutamic acid decarboxylase autoantibody (GADA) levels were higher among carriers of DQB1*06:02 when compared to those with other genotypes ( p = 0.033). Having a high‐risk haplotype paired with DQB1*06:02 ‐positive haplotype was associated with higher levels of islet antigen 2 autoantibodies (IA‐2A) ( p < 0.001) and somewhat shorter duration of symptoms ( p = 0.043). The association between the protective DQB1*06:02 allele and an older age at diagnosis as well as higher levels of GADA at diagnosis of type 1 diabetes was confirmed. The effects of the DQB1*06:02 ‐positive haplotype seem to dominate when paired with a high‐risk haplotype. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/tan.15720 |
| الاتاحة: | http://dx.doi.org/10.1111/tan.15720 https://onlinelibrary.wiley.com/doi/pdf/10.1111/tan.15720 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.5A8E3101 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/tan.15720 |
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