Academic Journal
Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers.
| العنوان: | Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers. |
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| المؤلفون: | Schantl, A.E., Verhulst, A., Neven, E., Behets, G.J., D'Haese, P.C., Maillard, M., Mordasini, D., Phan, O., Burnier, M., Spaggiari, D., Decosterd, L.A., MacAskill, M.G., Alcaide-Corral, C.J., Tavares, AAS, Newby, D.E., Beindl, V.C., Maj, R., Labarre, A., Hegde, C., Castagner, B., Ivarsson, M.E., Leroux, J.C. |
| المصدر: | Nature communications, vol. 11, no. 1, pp. 721 |
| سنة النشر: | 2020 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | 6-Phytase/metabolism, Adenine/adverse effects, Animals, Cells, Cultured, Drug Evaluation, Preclinical/methods, Dynamic Light Scattering, Ethylene Glycol/chemistry, Humans, Injections, Subcutaneous, Inositol Phosphates/chemistry, Inositol Phosphates/pharmacokinetics, Inositol Phosphates/pharmacology, Male, Muscle, Smooth, Vascular/cytology, Vascular/drug effects, Rats, Sprague-Dawley, Uremia/drug therapy, Uremia/physiopathology, Vascular Calcification/chemically induced, Vascular Calcification/drug therapy, X-Ray Diffraction |
| الوصف: | Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analogs as crystallization inhibitors, among which 4,6-di-O-(methoxy-diethyleneglycol)-myo-inositol-1,2,3,5-tetrakis(phosphate), (OEG |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32024848; info:eu-repo/semantics/altIdentifier/eissn/2041-1723; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_B322953EAB8C7; https://serval.unil.ch/notice/serval:BIB_B322953EAB8C; https://serval.unil.ch/resource/serval:BIB_B322953EAB8C.P001/REF.pdf |
| DOI: | 10.1038/s41467-019-14091-4 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_B322953EAB8C https://doi.org/10.1038/s41467-019-14091-4 https://serval.unil.ch/resource/serval:BIB_B322953EAB8C.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_B322953EAB8C7 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.5A48C4AF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-019-14091-4 |
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