التفاصيل البيبلوغرافية
| العنوان: |
Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C |
| المؤلفون: |
Oliver Strbak, Lucia Balejcikova, Martina Kmetova, Jan Gombos, Alzbeta Trancikova, Michal Pokusa, Peter Kopcansky |
| المصدر: |
International Journal of Molecular Sciences; Volume 21; Issue 17; Pages: 6332 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
ferritin, magnetoferritin, mineral core, reduction, ascorbic acid, riboflavin, ferrous ions, time dependence, toxicity |
| جغرافية الموضوع: |
agris |
| الوصف: |
Various pathological processes in humans are associated with biogenic iron accumulation and the mineralization of iron oxide nanoparticles, especially magnetite. Ferritin has been proposed as a precursor to pathological magnetite mineralization. This study quantifies spectroscopically the release of ferrous ions from native ferritin and magnetoferritin as a model system for pathological ferritin in the presence of potent natural reducing agents (vitamins C and B2) over time. Ferrous cations are required for the transformation of ferrihydrite (physiological) into a magnetite (pathological) mineral core and are considered toxic at elevated levels. The study shows a significant difference in the reduction and iron release from native ferritin compared to magnetoferritin for both vitamins. The amount of reduced iron formed from a magnetoferritin mineral core is two to five times higher than from native ferritin. Surprisingly, increasing the concentration of the reducing agent affects only iron release from native ferritin. Magnetoferritin cores with different loading factors seem to be insensitive to different concentrations of vitamins. An alternative hypothesis of human tissue magnetite mineralization and the process of iron-induced pathology is proposed. The results could contribute to evidence of the molecular mechanisms of various iron-related pathologies, including neurodegeneration. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Bioactives and Nutraceuticals; https://dx.doi.org/10.3390/ijms21176332 |
| DOI: |
10.3390/ijms21176332 |
| الاتاحة: |
https://doi.org/10.3390/ijms21176332 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.5A2D2C35 |
| قاعدة البيانات: |
BASE |