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CD4+ T Cell Immune Specificity Changes After Vaccination in Healthy And COVID-19 Convalescent Subjects

التفاصيل البيبلوغرافية
العنوان: CD4+ T Cell Immune Specificity Changes After Vaccination in Healthy And COVID-19 Convalescent Subjects
المؤلفون: Esparcia-Pinedo, Laura, Martinez-Fleta, Pedro, Ropero, Noelia, Vera-Tomé, Paula, Reyburn, H. T., Casasnovas, José María, Rodríguez Frade, José Miguel, Valés-Gómez, Mar, Vilches, Carlos, Martín-Gayo, Enrique, Muñoz-Calleja, Cecilia, Sánchez-Madrid, Francisco, Alfranca, Arántzazu
المساهمون: Instituto de Salud Carlos III, European Commission, Cooperativa de Viviendas Buen Suceso, Red de Investigación Cardiovascular (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), La Caixa, Banco Santander, Conferencia de Rectores de las Universidades Españolas, Comunidad de Madrid, Consejo Superior de Investigaciones Científicas (España)
بيانات النشر: Frontiers Media
سنة النشر: 2022
المجموعة: Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council)
مصطلحات موضوعية: T cell, Adaptive immunity, COVID-19, Vaccination, Immune profile
الوصف: The immune response promoted by SARS-CoV-2 vaccination is relevant to develop novel vaccines and optimized prevention strategies. We analyzed the adaptive immunity in healthy donors (HD) and convalescent individuals (CD), before and after administering BNT162b2 vaccine. Our results revealed specific changes in CD4+ T cell reactivity profile in vaccinated HD and CD, with an increase in S1 and S2 positive individuals, proportionally higher for S2. On the contrary, NCAP reactivity observed in HD and CD patients was no longer detectable after vaccination. Despite the substantial antibody response in CD, MPro-derived peptides did not elicit CD4+ lymphocyte activation in our assay in either condition. HD presented an increment in anti-S and anti-RBD IgG after first dose vaccination, which increased after the second vaccination. Conversely, anti-S and anti-RBD IgG and IgA titers increased in already positive CD after first dose administration, remaining stable after second dose inoculation. Interestingly, we found a strong significant correlation between S1-induced CD4+ response and anti-S IgA pre-vaccination, which was lost after vaccine administration. ; This work was supported by grants to AA: FIS PI19/01491 (Fondo de Investigación Sanitaria del Instituto de Salud Carlos III with co-funding from the Fondo Europeo de Desarrollo Regional FEDER) and Sociedad Cooperativa de Viviendas Buen Suceso, S.Coop.Mad. To AA and FS-M: CIBER Cardiovascular from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria del Instituto de Salud Carlos III with co-funding from the Fondo Europeo de Desarrollo Regional; FEDER). To FS-M: SAF2017-82886-R (Spanish Ministry of Economy and Competitiveness MINECO)), HR17-00016 (“La Caixa” Banking Foundation), “Fondos Supera COVID19” (Banco de Santander and CRUE), “Ayuda Covid 2019” and “Inmunovacter” REACT-UE (Comunidad de Madrid). To MV: Spanish National Research Council (CSIC, project number 202020E079 and CSIC-COVID19-028). ; Peer reviewed
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1664-3224
Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82886-R/ES/MECANISMOS INMUNO-REGULADORES EN LA COMUNICACION CELULA-CELULA: CONTACTOS SINAPTICOS PROMOTORES DEL ESTADO DE ALERTA EN CELULAS INMUNES/; Publisher's version; https://doi.org/10.3389/fimmu.2021.755891; Sí; Frontiers in Immunology 12: 755891 (2022); http://hdl.handle.net/10261/269279; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/100010784; http://dx.doi.org/10.13039/100012818; http://dx.doi.org/10.13039/501100003339; http://dx.doi.org/10.13039/501100000780
DOI: 10.3389/fimmu.2021.755891
DOI: 10.13039/501100004587
DOI: 10.13039/501100011033
DOI: 10.13039/100010784
DOI: 10.13039/100012818
DOI: 10.13039/501100003339
DOI: 10.13039/501100000780
الاتاحة: http://hdl.handle.net/10261/269279
https://doi.org/10.3389/fimmu.2021.755891
https://doi.org/10.13039/501100004587
https://doi.org/10.13039/501100011033
https://doi.org/10.13039/100010784
https://doi.org/10.13039/100012818
https://doi.org/10.13039/501100003339
https://doi.org/10.13039/501100000780
Rights: open
رقم الانضمام: edsbas.59E15DF2
قاعدة البيانات: BASE
الوصف
تدمد:16643224
DOI:10.3389/fimmu.2021.755891