Academic Journal
Solid-phase synthesis of NH-1,2,3-triazoles using 4,4′- bismethoxybenzhydryl azide
| العنوان: | Solid-phase synthesis of NH-1,2,3-triazoles using 4,4′- bismethoxybenzhydryl azide |
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| المؤلفون: | Cohrt, Anders Emil O'Hanlon, Le Quement, Sebastian Thordal, Nielsen, Thomas Eiland |
| المصدر: | Cohrt , A E OH , Le Quement , S T & Nielsen , T E 2014 , ' Solid-phase synthesis of NH-1,2,3-triazoles using 4,4′- bismethoxybenzhydryl azide ' , Synlett , vol. 25 , no. 13 , pp. 1891-1895 . https://doi.org/10.1055/s-0034-1378228 |
| سنة النشر: | 2014 |
| المجموعة: | Technical University of Denmark: DTU Orbit / Danmarks Tekniske Universitet |
| مصطلحات موضوعية: | Organic Chemistry, azide, click chemistry, cross-coupling, N H-1,2,3-triazoles, solid-phase synthesis, 1,2,3 triazole derivative, 4,4' bismethoxybenzhydryl azide, alkyne derivative, unclassified drug, article, chemical structure, cycloaddition, deprotection reaction, reaction analysis, solid phase synthesis, stoichiometry |
| الوصف: | Readily available 4,4′-bismethoxybenzhydryl azide was found to be a useful building block for the synthesis of NH-1,2,3-triazoles through copper(I)-catalyzed cycloaddition reactions with solid-supported terminal alkynes, followed by acid-mediated deprotection. Peptide-containing NH-1,2,3-triazoles were obtained in good yield and excellent purity (typically >95%) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://orbit.dtu.dk/en/publications/31765bd2-e024-4bde-997b-d0446f5f8a3c |
| DOI: | 10.1055/s-0034-1378228 |
| الاتاحة: | https://orbit.dtu.dk/en/publications/31765bd2-e024-4bde-997b-d0446f5f8a3c https://doi.org/10.1055/s-0034-1378228 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.59C96A62 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1055/s-0034-1378228 |
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