Academic Journal
A recent update on gastro retentive drug delivery systems
| العنوان: | A recent update on gastro retentive drug delivery systems |
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| المؤلفون: | Vinod Kumar, Sushma Somkuwar, Akhlesh Kumar Singhai |
| المصدر: | GSC Biological and Pharmaceutical Sciences, 27(1), 125–144, (2024-04-30) |
| بيانات النشر: | Zenodo |
| سنة النشر: | 2024 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Gastro retentive drug delivery system (GRDDS), Bio-adhesive, Mucoadhesive, Floating drug delivery system |
| الوصف: | Gastro retentive drug delivery systems (GRDDS) have garnered significant attention in recent years due to their potential to enhance therapeutic efficacy and patient compliance by prolonging gastric residence time and optimizing drug release kinetics. This review provides a comprehensive overview of the latest advancements in GRDDS, focusing on formulation strategies, design principles, and evaluation methodologies. Various approaches such as floating systems, mucoadhesive systems, expandable systems, and magnetic systems are discussed in detail, highlighting their mechanisms of action and applications in targeted drug delivery. Furthermore, recent innovations in materials science and formulation technologies have enabled the development of novel GRDDS with improved biocompatibility, stability, and controlled release profiles. The review also addresses challenges associated with GRDDS, including physiological variability, drug stability, and regulatory considerations, and proposes potential strategies to overcome these obstacles. Additionally, the clinical relevance of GRDDS in the treatment of various gastrointestinal disorders and their future prospects in personalized medicine and targeted therapy are explored. Overall, this review aims to provide valuable insights into the current state-of-the-art in GRDDS research and its implications for the advancement of drug delivery science. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://zenodo.org/communities/gscbps; https://doi.org/10.5281/zenodo.11960558; https://doi.org/10.5281/zenodo.11960559; oai:zenodo.org:11960559; https://doi.org/10.30574/gscbps.2024.27.1.0119 |
| DOI: | 10.5281/zenodo.11960559 |
| DOI: | 10.30574/gscbps.2024.27.1.0119 |
| الاتاحة: | https://doi.org/10.5281/zenodo.11960559 https://doi.org/10.30574/gscbps.2024.27.1.0119 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: | edsbas.5984AE82 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5281/zenodo.11960559 |
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