Academic Journal
Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry
| العنوان: | Sex‐related differences in left ventricular assist device utilization and outcomes: results from the PCHF‐VAD registry |
|---|---|
| المؤلفون: | Sumant P. Radhoe, Nina Jakus, Jesse F. Veenis, Philippe Timmermans, Anne‐Catherine Pouleur, Pawel Rubís, Emeline M. Van Craenenbroeck, Edvinas Gaizauskas, Eduardo Barge‐Caballero, Stefania Paolillo, Sebastian Grundmann, Domenico D'Amario, Oscar Ö. Braun, Aggeliki Gkouziouta, Ivo Planinc, Jana Ljubas Macek, Bart Meyns, Walter Droogne, Karol Wierzbicki, Katarzyna Holcman, Andreas J. Flammer, Hrvoje Gasparovic, Bojan Biocina, Davor Milicic, Lars H. Lund, Frank Ruschitzka, Jasper J. Brugts, Maja Cikes |
| المصدر: | ESC Heart Failure, Vol 10, Iss 2, Pp 1054-1065 (2023) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Advanced heart failure, Left ventricular assist device, Utilization, Sex, Survival, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Aims Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex‐related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort. Methods and results This analysis is part of the multicentre PCHF‐VAD registry studying continuous‐flow LVAD patients. The primary outcome was all‐cause mortality. Secondary outcomes included ventricular arrhythmias, right ventricular failure, bleeding, thromboembolism, and the haemocompatibility score. Multivariable Cox regression models were used to assess associations between sex and outcomes. Overall, 457 men (81%) and 105 women (19%) were analysed. At LVAD implant, women were more often in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile 1 or 2 (55% vs. 41%, P = 0.009) and more often required temporary mechanical circulatory support (39% vs. 23%, P = 0.001). Mean age was comparable (52.1 vs. 53.4 years, P = 0.33), and median follow‐up duration was 344 [range 147–823] days for women and 435 [range 190–816] days for men (P = 0.40). No significant sex‐related differences were found in all‐cause mortality (hazard ratio [HR] 0.79 for female vs. male sex, 95% confidence interval [CI] [0.50–1.27]). Female LVAD patients had a lower risk of ventricular arrhythmias (HR 0.56, 95% CI [0.33–0.95]) but more often experienced right ventricular failure. No significant sex‐related differences were found in other outcomes. Conclusions In this contemporary European cohort of LVAD patients, far fewer women than men underwent LVAD implantation despite similar clinical outcomes. This is important as the proportion of female LVAD patients (19%) was lower than the proportion of females with advanced HF as reported in previous studies, suggesting underutilization. Also, female patients were remarkably more often in INTERMACS profile 1 or 2, suggesting later referral for LVAD therapy. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2055-5822 |
| Relation: | https://doi.org/10.1002/ehf2.14261; https://doaj.org/toc/2055-5822; https://doaj.org/article/af6a877ad4424036a22d707ae6ab6d64 |
| DOI: | 10.1002/ehf2.14261 |
| الاتاحة: | https://doi.org/10.1002/ehf2.14261 https://doaj.org/article/af6a877ad4424036a22d707ae6ab6d64 |
| رقم الانضمام: | edsbas.597B3613 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20555822 |
|---|---|
| DOI: | 10.1002/ehf2.14261 |