Academic Journal
Palmitoylethanolamide and Luteolin for Postinfectious Olfactory Disorders: How Clinically Meaningful Is Its Effect?
| العنوان: | Palmitoylethanolamide and Luteolin for Postinfectious Olfactory Disorders: How Clinically Meaningful Is Its Effect? |
|---|---|
| المؤلفون: | Gellrich, Janine, Czaplewski, Linda, Hähner, Antje, Hummel, Thomas |
| المصدر: | ORL ; page 1-6 ; ISSN 0301-1569 1423-0275 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2024 |
| الوصف: | Introduction: The prevalence of post-viral olfactory dysfunction has increased significantly during the COVID-19 pandemic, posing a major challenge for patients and practitioners. While olfactory training (OT) is a common approach to therapy, there has been increasing interest in supplementing therapy with a combination of palmitoylethanolamide (PEA) and luteolin (LUT), which are known for their anti-inflammatory properties. In this study, their efficacy in the treatment of patients with olfactory loss following upper respiratory tract infections, mainly COVID-19, was investigated in an outpatient clinic. Methods: Fifty patients with persistent olfactory dysfunction were randomized to two groups: one receiving OT and PEA-LUT, the other OT alone. Olfactory function was evaluated before and after treatment. Results: The study group showed significant improvements in odor discrimination and overall olfactory function (TDI score) after treatment with PEA-LUT and OT, while the control group did not. However, when clinically meaningful improvements were considered, there was no significant difference between the groups. Conclusion: The present study suggests that while PEA-LUT may have the potential to improve olfactory function in post-viral dysfunction, the additional benefit over OT alone may be limited. These results contrast with some previous studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000539651 |
| DOI: | 10.1159/000539651/4252800/000539651.pdf |
| الاتاحة: | http://dx.doi.org/10.1159/000539651 https://karger.com/orl/article-pdf/doi/10.1159/000539651/4252800/000539651.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/ ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.59765E5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000539651 |
|---|