التفاصيل البيبلوغرافية
| العنوان: |
Synthesis, radiolabeling and biodistribution of a new opioid glucuronide derivative: ethyl-morphine glucuronide (em-glu) |
| المؤلفون: |
Enginar, H., Unak, P., Muftuler, F. Z. Biber, Lambrecht, F. Y., Kilcar, A. Yurt, Yolcular, S., Seyitoglu, B., Medine, E. I., Bulduk, I. |
| المصدر: |
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 292(2) 667-673 |
| سنة النشر: |
2012 |
| الوصف: |
In current study, ethyl-morphine (em) was synthesized from the morphine and glucuronidated via enzymatic mechanism. The conjugated glucuronide ethylmorphine (em-glu) was radiolabeled with I-131 using iodogen method. The quality control studies of radiolabeled compound (I-131-em-glu) were done with Thin Layer Radio Chromatography to confirm the radiolabeling efficiency. Biodistribution studies of I-131 labeled em-glu were run on healthy male Albino Wistar rats. The distribution figures demonstrated that I-131-em-glu was eliminated through the small intestine, large intestine and accumulated in urinary bladder both receptor blocked and unblocked biodistribution studies. A greater uptake of the radiolabeled substance was observed in the m. pons, hypothalamus and mid brain than in the other branches of the rats' brains. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://aperta.ulakbim.gov.tr/record/88887; oai:zenodo.org:88887 |
| الاتاحة: |
https://aperta.ulakbim.gov.tr/record/88887 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://www.opendefinition.org/licenses/cc-by |
| رقم الانضمام: |
edsbas.5957E371 |
| قاعدة البيانات: |
BASE |