Academic Journal
Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey.
| العنوان: | Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey. |
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| المؤلفون: | Adam, K.M., Osthoff, M., Lamoth, F., Conen, A., Erard, V., Boggian, K., Schreiber, P.W., Zimmerli, S., Bochud, P.Y., Neofytos, D., Fleury, M., Fankhauser, H., Goldenberger, D., Mühlethaler, K., Riat, A., Zbinden, R., Kronenberg, A., Quiblier, C., Marchetti, O., Khanna, N. |
| المساهمون: | Fungal Infection Network of Switzerland (FUNGINOS), Bregenzer, T., Conen, A., Adam, K.M., Flückiger, U., Khanna, N., Orasch, C., Heininger, U., Franciolli, M., San Giovanni, O., Damonti, L., Zimmerli, S., Rothen, M., Zellweger, C., Tarr, P., Fleisch, F., Chuard, C., Erard, V., Emonet, S., Garbino, J., Neofytos, D., van Delden, C., Genne, D., Bochud, P.Y., Calandra, T., Lamoth, F., Marchetti, O., Chave, J.P., Bois-Cerf, C., Cécil, C., La Source, C., Graber, P., Monotti, R., Regionale, O., Bernasconi, E., Civico, O., Rossi, M., Krause, M., Piso, R.J., Bally, F., Troillet, N., Boggian, K., Eich, G., Gubler, J., Fehr, J., Imhof, A., Ruef, C., Werner Schreiber, P., Berger, C., Fankhauser, H., Heinzer, I., Goldenberger, D., Frei, R., Hertel, R., Dolina, M., Petrini, O., Dubuis, O., Mühlethaler, K., Graf, S., Risch, M., Ritzler, E., Fracheboud, D., Riat, A., Rohner, P., Schrenzel, J., Lienhardt, R., Bille, J., Andreutti-Zaugg, C., Gallusser, A., Pfyffer, G., Herzog, K., Schibli, U., Tissière, L., Bruderer, T., Zbinden, R. |
| المصدر: | Open forum infectious diseases, vol. 8, no. 10, pp. ofab471 |
| سنة النشر: | 2021 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Infectious Diseases, Oncology, antifungals, candida, candidemia, epidemiology, resistance |
| الوصف: | The increasing incidence of candidemia and emergence of drug-resistant Candida species are major concerns worldwide. Long-term surveillance studies are needed. The Fungal Infection Network of Switzerland (FUNGINOS) conducted a 15-year (2004-2018), nationwide, epidemiological study of candidemia. Hospital-based incidence of candidemia, Candida species distribution, antifungal susceptibility, and consumption were stratified in 3 periods (2004-2008, 2009-2013, 2014-2018). Population-based incidence over the period 2009-2018 derived from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). A total of 2273 Candida blood isolates were studied. Population and hospital-based annual incidence of candidemia increased from 2.96 to 4.20/100 000 inhabitants (P = .022) and 0.86 to 0.99/10 000 patient-days (P = .124), respectively. The proportion of Candida albicans decreased significantly from 60% to 53% (P = .0023), whereas Candida glabrata increased from 18% to 27% (P < .0001). Other non-albicans Candida species remained stable. Candida glabrata bloodstream infections occurred predominantly in the age group 18-40 and above 65 years. A higher proportional increase of C glabrata was recorded in wards (18% to 29%, P < .0001) versus intensive care units (19% to 24%, P = .22). According to Clinical and Laboratory Standards Institute, nonsusceptibility to fluconazole in C albicans was observed in 1% of isolates, and anidulafungin and micafungin nonsusceptibility was observed in 2% of C albicans and C glabrata. Fluconazole consumption, the most frequently used antifungal, remained stable, whereas use of mold-active triazoles and echinocandins increased significantly in the last decade (P < .0001). Over the 15-year period, the incidence of candidemia increased. A species shift toward C glabrata was recently observed, concurring with increased consumption of mold-active triazoles. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34660836; info:eu-repo/semantics/altIdentifier/pissn/2328-8957; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E1C2CA5BE7235; https://serval.unil.ch/notice/serval:BIB_E1C2CA5BE723; http://dx.doi.org/10.1093/ofid/ofab471; https://serval.unil.ch/resource/serval:BIB_E1C2CA5BE723.P002/REF.pdf |
| DOI: | 10.1093/ofid/ofab471 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_E1C2CA5BE723 https://doi.org/10.1093/ofid/ofab471 https://serval.unil.ch/resource/serval:BIB_E1C2CA5BE723.P002/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_E1C2CA5BE7235 |
| Rights: | info:eu-repo/semantics/openAccess ; CC BY-NC-ND 4.0 ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.594B9870 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ofid/ofab471 |
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