Academic Journal
Population-Based Risk of Psychiatric Disorders Associated With Recurrent Copy Number Variants
| العنوان: | Population-Based Risk of Psychiatric Disorders Associated With Recurrent Copy Number Variants |
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| المؤلفون: | Vaez, Morteza, Montalbano, Simone, Sánchez, Xabier Calle, Georgii Hellberg, Kajsa-Lotta, Dehkordi, Saeid Rasekhi, Krebs, Morten Dybdahl, Meijsen, Joeri, Shorter, John, Bybjerg-Grauholm, Jonas, Mortensen, Preben B., Børglum, Anders D., Hougaard, David M., Nordentoft, Merete, Geschwind, Daniel H., Buil, Alfonso, Schork, Andrew J., Helenius, Dorte, Raznahan, Armin, Thompson, Wesley K., Werge, Thomas, Ingason, Andrés |
| المصدر: | Vaez , M , Montalbano , S , Sánchez , X C , Georgii Hellberg , K-L , Dehkordi , S R , Krebs , M D , Meijsen , J , Shorter , J , Bybjerg-Grauholm , J , Mortensen , P B , Børglum , A D , Hougaard , D M , Nordentoft , M , Geschwind , D H , Buil , A , Schork , A J , Helenius , D , Raznahan , A , Thompson , W K , Werge , T , Ingason , A & iPSYCH Investigators 2024 , ' .... |
| سنة النشر: | 2024 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| الوصف: | IMPORTANCE: Recurrent copy number variants (rCNVs) have been associated with increased risk of psychiatric disorders in case-control studies, but their population-level impact is unknown. OBJECTIVE: To provide unbiased population-based estimates of prevalence and risk associated with psychiatric disorders for rCNVs and to compare risks across outcomes, rCNV dosage type (deletions or duplications), and locus features. DESIGN, SETTING, AND PARTICIPANTS: This genetic association study is an analysis of data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) case-cohort sample of individuals born in Denmark in 1981-2008 and followed up until 2015, including (1) all individuals (n = 92 531) with a hospital discharge diagnosis of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder, major depressive disorder (MDD), or schizophrenia spectrum disorder (SSD) and (2) a subcohort (n = 50 625) randomly drawn from the source population. Data were analyzed from January 2021 to August 2023. EXPOSURES: Carrier status of deletions and duplications at 27 autosomal rCNV loci was determined from neonatal blood samples genotyped on single-nucleotide variant microarrays. MAIN OUTCOMES AND MEASURES: Population-based rCNV prevalence was estimated with a survey model using finite population correction to account for oversampling of cases. Hazard ratio (HR) estimates and 95% CIs for psychiatric disorders were derived using weighted Cox proportional hazard models. Risks were compared across outcomes, dosage type, and locus features using generalized estimating equation models. RESULTS: A total of 3547 rCNVs were identified in 64 735 individuals assigned male at birth (53.8%) and 55 512 individuals assigned female at birth (46.2%) whose age at the end of follow-up ranged from 7.0 to 34.7 years (mean, 21.8 years). Most observed increases in rCNV-associated risk for ADHD, ASD, or SSD were moderate, and risk estimates were highly correlated across these disorders. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1001/jamapsychiatry.2024.1453 |
| الاتاحة: | https://researchprofiles.ku.dk/da/publications/populationbased-risk-of-psychiatric-disorders-associated-with-recurrent-copy-number-variants(adec1ca6-9966-419b-871b-cd07b3c70548).html https://doi.org/10.1001/jamapsychiatry.2024.1453 https://curis.ku.dk/ws/files/411760545/jamapsychiatry_vaez_2024_oi_240033_1727819431.79104.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5921B297 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamapsychiatry.2024.1453 |
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