Academic Journal
Efficacy and safety of Zhishixiaopi decoction in functional dyspepsia: A meta-analysis of randomized controlled trials
| العنوان: | Efficacy and safety of Zhishixiaopi decoction in functional dyspepsia: A meta-analysis of randomized controlled trials |
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| المؤلفون: | Zhao, Xiankun, Cheng, Xinyu, Ye, Jing, Ren, Jiaqing, Li, Bin, Tan, Dongmei, Li, Tangshan, Zhou, Kai, Pu, Jing, Luo, Xia, Feng, Yong |
| المساهمون: | Dida, Gabriel O., The Sichuan Nursing Society, The Key Research Base of Humanities and Social Sciences in Colleges and Universities in Sichuan Province, Sichuan Traditional Chinese Medicine Culture Cooperative Development Research Center |
| المصدر: | PLOS ONE ; volume 19, issue 5, page e0301686 ; ISSN 1932-6203 |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2024 |
| المجموعة: | PLOS Publications (via CrossRef) |
| الوصف: | Background Functional dyspepsia (FD) refers to a group of clinical symptoms caused by gastric and duodenal dysfunction. Which is a chronic functional disorder of the gastrointestinal tract with no cure. Zhishixiaopi decoction (ZSXP) is a type of Chinese herbal prescription that for treating FD. Although some randomized controlled trials (RCTs) report that ZSXP can significantly improve FD clinical symptoms and/or laboratory results, the trial design varies greatly among studies, making it challenging to draw a conclusion of the efficacy of ZSXP in treating FD. Design A systematic review and a meta-analysis. Setting Mianyang Central Hospital. Objective We conducted a systematic review and a meta-analysis to evaluate the efficacy and safety of ZSXP for treating FD. Methods We developed inclusion and exclusion criteria based on FD diagnosed criteria, interventions to treat FD, and outcomes of these interventions. Search strategies combined disease terms, symptom terms, anatomy terms and intervention terms. Literature search was conducted on eight online databases in English or Chinese, including Medline (via PubMed), Embase (via Ovid), The Cochrane Library, Web of Science, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), and Wanfang Database. Intervention The experimental group received oral administration of ZSXP and had a complete treatment process. ZSXP needs to fully contain the key herbal ingredients, regardless of whether the dosage of each herb is consistent with the original prescription. The Control group received monotherapy or combination therapy of other Western medicine and had a complete treatment process. Outcomes The primary outcomes appraised were Total effective rate (TER), serum levels of Motilin(MOT), Gastrin(GAS) and Somatostatin (SS), Gastric emptying rate (GER) using a Barium meal method (GER(B)) and Gastric half emptying time using an Ultrasonic method (GHET(T 1/2 )). The Cochrane Bias Risk Tool was used for quality ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1371/journal.pone.0301686 |
| الاتاحة: | http://dx.doi.org/10.1371/journal.pone.0301686 https://dx.plos.org/10.1371/journal.pone.0301686 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.59075160 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0301686 |
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