Academic Journal
Apelin/APJ‐Manipulated CaMKK/AMPK/GSK3β Signaling Works as an Endogenous Counterinjury Mechanism in Promoting the Vitality of Random‐Pattern Skin Flaps
| العنوان: | Apelin/APJ‐Manipulated CaMKK/AMPK/GSK3β Signaling Works as an Endogenous Counterinjury Mechanism in Promoting the Vitality of Random‐Pattern Skin Flaps |
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| المؤلفون: | Lou, Zhi-Ling, Zhang, Chen-Xi, Li, Jia-Feng, Chen, Rui-Heng, Wu, Wei-Jia, Hu, Xiao-Fen, Shi, Hao-Chun, Gao, Wei-Yang, Zhao, Qi-Feng |
| المساهمون: | Gon alves, Reggiani Vilela, National Natural Science Foundation of China, Natural Science Foundation of Zhejiang Province |
| المصدر: | Oxidative Medicine and Cellular Longevity ; volume 2021, issue 1 ; ISSN 1942-0900 1942-0994 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | A random‐pattern skin flap plays an important role in the field of wound repair; the mechanisms that influence the survival of random‐pattern skin flaps have been extensively studied but little attention has been paid to endogenous counterinjury substances and mechanism. Previous reports reveal that the apelin‐APJ axis is an endogenous counterinjury mechanism that has considerable function in protecting against infection, inflammation, oxidative stress, necrosis, and apoptosis in various organs. As an in vivo study, our study proved that the apelin/APJ axis protected the skin flap by alleviating vascular oxidative stress and the apelin/APJ axis works as an antioxidant stress factor dependent on CaMKK/AMPK/GSK3 β signaling. In addition, the apelin/APJ‐manipulated CaMKK/AMPK/GSK3 β ‐dependent mechanism improves HUVECs’ resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro. Besides, activation of the apelin/APJ axis promotes vascular migration and angiogenesis under relative hypoxia condition through CaMKK/AMPK/GSK3 β signaling. In a word, we provide new evidence that the apelin/APJ axis is an effective antioxidant and can significantly improve the vitality of random flaps, so it has potential be a promising clinical treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1155/2021/8836058 |
| الاتاحة: | http://dx.doi.org/10.1155/2021/8836058 http://downloads.hindawi.com/journals/omcl/2021/8836058.pdf http://downloads.hindawi.com/journals/omcl/2021/8836058.xml https://onlinelibrary.wiley.com/doi/pdf/10.1155/2021/8836058 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.58D212D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2021/8836058 |
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