Academic Journal
Estimation of Alpha-Amylase in Smokers with and without Leukoplakia and Oral Cancer—A Comparative Study
| العنوان: | Estimation of Alpha-Amylase in Smokers with and without Leukoplakia and Oral Cancer—A Comparative Study |
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| المؤلفون: | Amit A. Basannavar, Ankita Bhargava, Alkananda Sahoo, Nidhi Dhakar, Rahul R. Shetty, Debanti Giri |
| المصدر: | Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss Suppl 4, Pp S3200-S3202 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | alpha-amylase, biomarker, comparative study, leukoplakia, oral cancer, saliva, smokers, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142 |
| الوصف: | Background: Alpha-amylase is an enzyme found in saliva that plays a crucial role in the initial stages of digestion. Its levels can be influenced by various factors, including lifestyle habits such as smoking. Materials and Methods: A total of 150 male subjects were recruited for this comparative study and divided into three groups: 50 smokers without any oral lesions (group A), 50 smokers with leukoplakia (group B), and 50 smokers with oral cancer (group C). Salivary samples were collected from each participant and analyzed for alpha-amylase activity using the 2-chloro-4-nitrophenyl-β-D-maltotrioside (CNPG3) method. Data were statistically analyzed using ANOVA and post-hoc tests to compare the mean alpha-amylase levels between the groups. Results: The mean alpha-amylase levels were found to be 140 U/mL in group A, 180 U/mL in group B, and 220 U/mL in group C. Statistical analysis revealed a significant increase in alpha-amylase levels in smokers with leukoplakia and oral cancer compared to smokers without oral lesions (P < 0.05). Moreover, a significant difference was observed between group B and group C (P < 0.05), indicating progressively higher enzyme levels with the severity of the oral condition. Conclusion: The study demonstrates that salivary alpha-amylase levels are elevated in smokers with leukoplakia and oral cancer compared to those without these conditions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://journals.lww.com/10.4103/jpbs.jpbs_690_24; https://doaj.org/toc/0976-4879; https://doaj.org/toc/0975-7406; https://doaj.org/article/fb00c929958b42f5b49e3fa9514c980f |
| DOI: | 10.4103/jpbs.jpbs_690_24 |
| الاتاحة: | https://doi.org/10.4103/jpbs.jpbs_690_24 https://doaj.org/article/fb00c929958b42f5b49e3fa9514c980f |
| رقم الانضمام: | edsbas.58C18E63 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4103/jpbs.jpbs_690_24 |
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